Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2273233..2273756 Replicon chromosome
Accession NZ_CP062338
Organism Staphylococcus aureus strain NAS_NP_103

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IF745_RS11095 Protein ID WP_000074046.1
Coordinates 2273490..2273756 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K4AGF2
Locus tag IF745_RS11090 Protein ID WP_000587615.1
Coordinates 2273233..2273490 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF745_RS11070 (2268328) 2268328..2269521 + 1194 WP_000675403.1 MFS transporter -
IF745_RS11075 (2269745) 2269745..2270494 - 750 WP_000019956.1 CPBP family lipoprotein N-acylation protein LnsB -
IF745_RS11080 (2270684) 2270684..2272261 + 1578 WP_000143490.1 FMN-binding glutamate synthase family protein -
IF745_RS11085 (2272411) 2272411..2272875 - 465 WP_000736689.1 DUF1307 domain-containing protein -
IF745_RS11090 (2273233) 2273233..2273490 + 258 WP_000587615.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF745_RS11095 (2273490) 2273490..2273756 + 267 WP_000074046.1 Txe/YoeB family addiction module toxin Toxin
IF745_RS11100 (2274069) 2274069..2275145 + 1077 WP_001076667.1 M42 family metallopeptidase -
IF745_RS11105 (2275393) 2275393..2276055 + 663 WP_000923528.1 ATP-binding cassette domain-containing protein -
IF745_RS11110 (2276048) 2276048..2276821 + 774 WP_000072148.1 iron export ABC transporter permease subunit FetB -
IF745_RS11115 (2277173) 2277173..2278357 + 1185 WP_000115415.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10658.27 Da        Isoelectric Point: 10.1384

>T174396 WP_000074046.1 NZ_CP062338:2273490-2273756 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174396 NZ_CP081007:2568921-2569250 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9746.68 Da        Isoelectric Point: 4.1111

>AT174396 WP_000587615.1 NZ_CP062338:2273233-2273490 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174396 NZ_CP081007:2568583-2568900 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AGF2

References