Detailed information of TA system TA174393

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 165226..165406
• Replicon: chromosome
• Accession: NZ_CP062338
• Organism: Staphylococcus aureus strain NAS_NP_103

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF745_RS01045
• Protein ID: WP_001801861.1
• Coordinates: 165311..165406 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	165226..165283 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF745_RS01015	161577..162695	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF745_RS01020	163343..163786	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF745_RS01025	164014..164343	+	330	WP_223294405.1	DUF1433 domain-containing protein	-
IF745_RS01030	164365..164739	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF745_RS01035	164927..165109	+	183	Protein_168	transposase	-
IF745_RS01040	165087..165188	-	102	WP_001791232.1	hypothetical protein	-
-	165226..165283	+	58	-	-	Antitoxin
IF745_RS01045	165311..165406	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF745_RS01050	165857..166303	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF745_RS01055	166988..167371	+	384	WP_000070811.1	hypothetical protein	-
IF745_RS01060	167382..167558	+	177	WP_000375476.1	hypothetical protein	-
IF745_RS01065	167858..168486	+	629	Protein_174	ImmA/IrrE family metallo-endopeptidase	-
IF745_RS01070	168684..169256	-	573	Protein_175	hypothetical protein	-
IF745_RS01075	169357..169698	-	342	WP_000627548.1	DUF3969 family protein	-
IF745_RS01080	169739..170365	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	143689..191223	47534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174393 WP_001801861.1 NZ_CP062338:c165406-165311 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174393 NZ_CP081007:c1849050-1848832 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174393 NZ_CP062338:165226-165283 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin