Detailed information of TA system TA174391

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 18899..19206
• Replicon: chromosome
• Accession: NZ_CP062338
• Organism: Staphylococcus aureus strain NAS_NP_103

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF745_RS00105
• Protein ID: WP_072357969.1
• Coordinates: 18899..19075 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	19065..19206 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF745_RS00085	14066..17848	+	3783	WP_000582177.1	phage tail spike protein	-
IF745_RS00090	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF745_RS00095	18039..18326	+	288	WP_240029497.1	hypothetical protein	-
IF745_RS00100	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF745_RS00105	18899..19075	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19065..19206	-	142	-	-	Antitoxin
IF745_RS00115	19287..19541	+	255	WP_000611512.1	phage holin	-
IF745_RS00120	19553..20308	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF745_RS00125	20499..20990	+	492	WP_000920041.1	staphylokinase	-
IF745_RS00130	21512..21862	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF745_RS00135	21915..22175	-	261	WP_001791826.1	hypothetical protein	-
IF745_RS00140	22486..22665	-	180	WP_000669789.1	hypothetical protein	-
IF745_RS00145	23037..23234	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..21862	21861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174391 WP_072357969.1 NZ_CP062338:18899-19075 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174391 NZ_CP081007:1363664-1364128 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Nucleotide

• Length: 142 bp

>AT174391 NZ_CP062338:c19206-19065 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin