Detailed information of TA system TA174387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2724360..2724783
• Replicon: chromosome
• Accession: NZ_CP062336
• Organism: Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IF748_RS13415
• Protein ID: WP_086097839.1
• Coordinates: 2724360..2724611 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IF748_RS13420
• Protein ID: WP_086097840.1
• Coordinates: 2724601..2724783 (+)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF748_RS13355 (2720024)	2720024..2720173	+	150	WP_001081076.1	hypothetical protein	-
IF748_RS13360 (2720166)	2720166..2720447	-	282	WP_000414755.1	hypothetical protein	-
IF748_RS13365 (2720513)	2720513..2721283	+	771	WP_000190253.1	conserved phage C-terminal domain-containing protein	-
IF748_RS13370 (2721293)	2721293..2722072	+	780	WP_000803062.1	ATP-binding protein	-
IF748_RS13375 (2722066)	2722066..2722227	+	162	WP_000237154.1	hypothetical protein	-
IF748_RS13380 (2722240)	2722240..2722461	+	222	WP_001556702.1	DUF3269 family protein	-
IF748_RS13385 (2722471)	2722471..2722875	+	405	WP_000049801.1	DUF1064 domain-containing protein	-
IF748_RS13390 (2722880)	2722880..2723065	+	186	WP_240029712.1	DUF3113 family protein	-
IF748_RS13395 (2723066)	2723066..2723425	+	360	WP_106459739.1	SA1788 family PVL leukocidin-associated protein	-
IF748_RS13400 (2723426)	2723426..2723674	+	249	WP_001126836.1	phi PVL orf 51-like protein	-
IF748_RS13405 (2723688)	2723688..2724092	+	405	WP_240029713.1	hypothetical protein	-
IF748_RS13410 (2724092)	2724092..2724367	+	276	WP_072473441.1	hypothetical protein	-
IF748_RS13415 (2724360)	2724360..2724611	+	252	WP_086097839.1	DUF1024 family protein	Toxin
IF748_RS13420 (2724601)	2724601..2724783	+	183	WP_086097840.1	hypothetical protein	Antitoxin
IF748_RS13425 (2724776)	2724776..2725312	+	537	WP_000185680.1	dUTPase	-
IF748_RS13430 (2725349)	2725349..2725555	+	207	WP_000195827.1	DUF1381 domain-containing protein	-
IF748_RS13435 (2725552)	2725552..2725752	+	201	WP_000573772.1	hypothetical protein	-
IF748_RS13440 (2725745)	2725745..2725894	+	150	WP_000595240.1	hypothetical protein	-
IF748_RS13445 (2725894)	2725894..2726094	+	201	WP_000265043.1	DUF1514 family protein	-
IF748_RS13450 (2726117)	2726117..2726578	+	462	WP_000282745.1	hypothetical protein	-
IF748_RS13455 (2726693)	2726693..2727145	+	453	WP_000406191.1	nucleoside triphosphate pyrophosphohydrolase family protein	-
IF748_RS13460 (2727161)	2727161..2727505	+	345	WP_000817289.1	HNH endonuclease	-
IF748_RS13465 (2727635)	2727635..2728102	+	468	WP_000919026.1	phage terminase small subunit P27 family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2710025..2728102	18077

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9527.44 Da
• Isoelectric Point: 3.7128

>T174387 WP_086097839.1 NZ_CP062336:2724360-2724611 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDIYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T174387 NZ_CP081006:c1665760-1665401 [Mycobacterium sp. IDR2000157661]
ATGGTCGATCTACTTGCTCGCACGGATGATCGGTATCCGGCGGTACGCGCACGGCTGGCTAATACGGTGATGCATGCGCC
GGCACACTTCGACGCCGAGGTGTTGTCGGCGCTCGGTCGCATGCAACGTGCCGGTGTGCTCACCGTTGCGCAGGTCGATG
TGGCGCTGAGTGAGTTGAGCCAGGCACCGATGACCCGCCACGATCTGGCTCCGCTGCTTGTTGGCGCATGGGCACGCCGT
GAGACTCTTCGCCTCACCGACGCGTTCTACGTCGAACTCGCCGATACCGCAGATTTCGTGCTGCTGACCACGGATCAGCG
CTTGGCTCGCGCTTGGCCTCTCGCCGATGCGATCGACTAA

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6793.71 Da
• Isoelectric Point: 4.4421

>AT174387 WP_086097840.1 NZ_CP062336:2724601-2724783 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDIHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Nucleotide

• Length: 183 bp

>AT174387 NZ_CP081006:c1666095-1665811 [Mycobacterium sp. IDR2000157661]
ATGCGTGGCCCGGACCGAACTAGGCGCTTGGGGTCGACATACGCGAGTGTGTGTATATTGGTGTGTATGGCCCGGTTGAA
TGTGTACGTCCCAGACGAGCTGGCCGAACGCGCAAGGGCGCTGGGCTTGAATATCTCGGCGTTGACGCAGGCAGCGATCA
GCGCTGAGCTGGAGCGTTCTGGCACCGAGGCATGGCTTGACCGGCTGGAGGCCAGAGGCACCGGCGCTCGGCATGACGAC
GTGCTTGATGCGATCGATGCCGCCCGTGACGAGTTCGGAGCGTGA