Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2118216..2118739 Replicon chromosome
Accession NZ_CP062336
Organism Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag IF748_RS10560 Protein ID WP_000074045.1
Coordinates 2118216..2118482 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag IF748_RS10565 Protein ID WP_000587619.1
Coordinates 2118482..2118739 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF748_RS10540 (2113522) 2113522..2114709 - 1188 WP_000026194.1 MFS transporter -
IF748_RS10545 (2115105) 2115105..2115881 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF748_RS10550 (2115874) 2115874..2116536 - 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
IF748_RS10555 (2116784) 2116784..2117860 - 1077 WP_001076673.1 M42 family metallopeptidase -
IF748_RS10560 (2118216) 2118216..2118482 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
IF748_RS10565 (2118482) 2118482..2118739 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF748_RS10570 (2119098) 2119098..2119553 + 456 WP_000732082.1 DUF1307 domain-containing protein -
IF748_RS10575 (2119721) 2119721..2121298 - 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
IF748_RS10580 (2121493) 2121493..2122242 + 750 WP_000072464.1 CPBP family lipoprotein N-acylation protein LnsB -
IF748_RS10585 (2122466) 2122466..2123659 - 1194 WP_000675406.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T174386 WP_000074045.1 NZ_CP062336:c2118482-2118216 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T174386 NZ_CP081006:1648379-1648819 [Mycobacterium sp. IDR2000157661]
GTGAAGGTCGTCGACGCCAGCATCCTCCTTTACTCCGTGAATTCGGCCAGCGAGCATCACGAGGCTTGTCGTGAATGGCT
TGACGGGGCATTGTCCGGATCGGACACCGTGGGGTTGGCGTGGGTGCCGTTGCTCGCCTTCGTCCGGCTGAGCACCAAGG
TGGGCCTGTTCCCTTCGCCGTTACCGCCGTCAGAGGCGATGCGCCAGGTCGTCGACTGGTCGACTGCTCCCGGTGCGACT
GTGATCGCACCGACGCCACGGCACGGCGACATCCTGCACGGGCTGCTCGCGAACGTCGGCACGGGCGGAAACCTCGTCAA
CGACGCCCACCTGGCCGCTCTCACCATCGAGCACCGGGCATCGATCGTCAGCTATGACAACGACTTCGGCCGGTTCGACG
GGATACGGTGGGACACCCCGGACGCGTTACTCGCCCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT174386 WP_000587619.1 NZ_CP062336:c2118739-2118482 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174386 NZ_CP081006:1648128-1648382 [Mycobacterium sp. IDR2000157661]
ATGCGCACGACGGTCACGCTCGACGACGACACGCTGGCACTGATCCGGCGGCGCATGCGCGAACAGGGCGTCTCTTTCAA
GACCGCGCTCAACGACGCGATCCGCGACGGCGCATTCGGCCGACCTCCGGCGACCCGGTTCGTGACCCGTTCAGCCGACC
TCGGAGTCCCGACGGTGAACCTGGACCGAGCCCTGCAAATCGCCGGCGAACTCGAAGACGAAGAACTGCTGCGCCGGCAA
CGGCGGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References