Detailed information of TA system TA174384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2086669..2086853
• Replicon: chromosome
• Accession: NZ_CP062336
• Organism: Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF748_RS10420
• Protein ID: WP_000482647.1
• Coordinates: 2086746..2086853 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2086669..2086729 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF748_RS10405	2082123..2082290	-	168	WP_001792506.1	hypothetical protein	-
IF748_RS10410	2082521..2084254	-	1734	WP_000486496.1	ABC transporter ATP-binding protein	-
IF748_RS10415	2084279..2086042	-	1764	WP_001064836.1	ABC transporter ATP-binding protein	-
-	2086669..2086729	+	61	-	-	Antitoxin
IF748_RS10420	2086746..2086853	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF748_RS10425	2086987..2087373	-	387	WP_000779360.1	flippase GtxA	-
IF748_RS10430	2087631..2088773	+	1143	WP_001176863.1	glycerate kinase	-
IF748_RS10435	2088833..2089492	+	660	WP_000831295.1	hypothetical protein	-
IF748_RS10440	2089674..2090885	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF748_RS10445	2091008..2091481	-	474	WP_000456492.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174384 WP_000482647.1 NZ_CP062336:c2086853-2086746 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174384 NZ_CP081006:c864566-864171 [Mycobacterium sp. IDR2000157661]
GTGACGGTGCTTCTCGATGCGAACGTGCTCATCGCACTGGTGGTGGCCGAGCACGTCCATCACGACGCGTCCACGGAGTG
GCTGGCCGCATCGACTATCGACTTCGCCACATGTCCGGTGACTCAGGGAAGTCTGGTTCGCTTCCTCGTGCGTTCGGGGC
AATCTGCCGCGTCCGCGCGCGATGTGGTCCGTGCATTGGAAGCGTCTGAGCGGCATACCTTTTGGCCGGATGCCATTTCA
TTCGCAAGTGTGAAGGTGAAGGGAATCGTCGGGCACCGTCAAGTAACCGACGCGTATCTCGCTCAGCTCACCAGAACAAA
CAACGGACAGTTGGCGACGCTCGACGCTGGATTGGCCCATCTTCATGACGACGTCGCGATTCTCATACCGACGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174384 NZ_CP062336:2086669-2086729 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin