Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2061360..2061877 Replicon chromosome
Accession NZ_CP062336
Organism Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF748_RS10285 Protein ID WP_000113262.1
Coordinates 2061360..2061626 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF748_RS10290 Protein ID WP_000584499.1
Coordinates 2061626..2061877 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF748_RS10255 (2056783) 2056783..2057319 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
IF748_RS10260 (2057553) 2057553..2058377 - 825 WP_000572040.1 formate/nitrite transporter family protein -
IF748_RS10265 (2058594) 2058594..2058776 - 183 WP_000079142.1 hypothetical protein -
IF748_RS10270 (2058863) 2058863..2059330 - 468 WP_000153344.1 SRPBCC domain-containing protein -
IF748_RS10275 (2059516) 2059516..2061066 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF748_RS10280 (2061254) 2061254..2061325 - 72 WP_223200558.1 hypothetical protein -
IF748_RS10285 (2061360) 2061360..2061626 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF748_RS10290 (2061626) 2061626..2061877 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF748_RS10295 (2062042) 2062042..2062122 - 81 WP_223197974.1 hypothetical protein -
IF748_RS10300 (2062150) 2062150..2062749 - 600 WP_240029698.1 DsbA family protein -
IF748_RS10305 (2062768) 2062768..2063130 - 363 WP_240029699.1 DUF4467 domain-containing protein -
IF748_RS10310 (2063385) 2063385..2064635 + 1251 WP_031837522.1 FemA/FemB family glycyltransferase FmhA -
IF748_RS10315 (2064732) 2064732..2065463 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF748_RS10320 (2065460) 2065460..2066179 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174383 WP_000113262.1 NZ_CP062336:c2061626-2061360 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174383 NZ_CP081005:c124903-124556 [Mycobacterium sp. IDR2000157661]
GTGACCCCGGCGCGAGGCCAGGTGTATCGCTGCGATCTCGGCTACGGCGCCAAACCGTGGCTGATCGTGTCCAACAACCA
ACGCAACCGCCACACCGCCGACGTGGTCGCCATCCGACTGACGACCACGTCCCGCCGGCTCCCAACCTGGGTGGCACTCG
CCAGCAGCGATCCGCTGACCGGCTACGCGAACGCCGACAACATCGAAACGCTCGCTAAAGACGAACTCGGCGACTACCTC
GGTGCGCTGTCGCCGGCCACCATGGCCCGCGTCAATACCGCGCTTGCCATCGCGCTCGCCCTGCCCGCGGGGCGCTCCCC
TCGGCCACAACCCCCGCCCACGCATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174383 WP_000584499.1 NZ_CP062336:c2061877-2061626 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174383 NZ_CP081005:c125172-124906 [Mycobacterium sp. IDR2000157661]
ATGGCGGAAGAATACTCCACACGATTGCGACTCGATGCGTCCACACATCAGCGCCTGCAAGACATTGTCGGAAAGGGCCA
CTACCGCAGCAGCAATGCCGCCATCGTGGACGCCATCAACCGTCTCTGGGACCACGTCTGCGAGCAGGAACTCGACGCGG
CCTACGCCGCCGCGGTTGCCGAGAATCCCTCGTATCCATACGAATCCGTCGCCGAGCGCGCGGCCGCGCGCGCCCGGCGT
AACCGACGCCAGGCGGTCAGCGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References