Detailed information of TA system TA174382

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 1804736..1804933
• Replicon: chromosome
• Accession: NZ_CP062336
• Organism: Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF748_RS08945
• Protein ID: WP_001802298.1
• Coordinates: 1804829..1804933 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1804736..1804774 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF748_RS08920	1799753..1800073	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF748_RS08925	1800075..1801055	+	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IF748_RS08930	1801321..1802412	+	1092	WP_000495672.1	hypothetical protein	-
IF748_RS08935	1802441..1804087	-	1647	WP_000277718.1	IS1182 family transposase	-
IF748_RS08940	1804716..1804790	+	75	Protein_1721	hypothetical protein	-
-	1804736..1804774	+	39	-	-	Antitoxin
IF748_RS08945	1804829..1804933	-	105	WP_001802298.1	hypothetical protein	Toxin
IF748_RS08950	1805613..1805771	+	159	WP_001792784.1	hypothetical protein	-
IF748_RS08955	1806430..1807287	-	858	WP_240029689.1	HAD family hydrolase	-
IF748_RS08960	1807355..1808137	-	783	WP_000908174.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1802441..1804087	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174382 WP_001802298.1 NZ_CP062336:c1804933-1804829 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174382 NZ_CP081002:c882639-882154 [Sphingobium sp. V4]
GTGACGACGAGCTTCTGGAGGATCGCCACTGACACCAAGGCCTATGAGGCCGACGACATGACGGGCGCCGGCGCGAAGAT
CACGGGCGGCCGCTGGAATGACGTCGGCATCGCTCTTGTCTATGCGGCAAGCAACCGGGCGCTCGCCTGCCTTGAAACCG
TCGTCCATCTCAATAGCGGAGGGCTGCCGCTCAACCGCTTTCTTGTCGAAATCGCGGTACCCGACGACATGCTGGCTGCG
GCGGAGTTCGCCACGGGTGGAAGTCTGGCGGTCGGTTGGGATGCCGAGCCGGCCGGCAGAGTCAGCATTTCGTTCGGGTC
GGCATGGGCGCAGTCCCTGCGCACGGCGTTGATGCTCGTCCCCTCGGTCATCGTGCCCGAGGAGCAGAATCTGCTCATCA
ATCCCGCGCACCCGGACGCAGGACGGATCACGGCTCGCAAGGTGCGTAAATGGCTCTATGACCCCCGGATGATCCGCAAA
GCCTGA

Antitoxin

Nucleotide

• Length: 39 bp

>AT174382 NZ_CP062336:1804736-1804774 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin