Detailed information of TA system TA174373

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19215..19553
• Replicon: chromosome
• Accession: NZ_CP062336
• Organism: Staphylococcus aureus strain NAS_NP_161

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF748_RS00100
• Protein ID: WP_072357969.1
• Coordinates: 19215..19391 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19379..19553 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF748_RS00080	14381..18166	+	3786	WP_240029715.1	phage tail spike protein	-
IF748_RS00085	18156..18308	+	153	WP_000654329.1	hypothetical protein	-
IF748_RS00090	18355..18642	+	288	WP_001040255.1	hypothetical protein	-
IF748_RS00095	18698..19072	+	375	WP_000340977.1	hypothetical protein	-
IF748_RS00100	19215..19391	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19379..19553	-	175	-	-	Antitoxin
IF748_RS00110	19603..19857	+	255	WP_000611512.1	phage holin	-
IF748_RS00115	19869..20624	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF748_RS13590	21157..21279	+	123	WP_000346420.1	hypothetical protein	-
IF748_RS00120	21521..22348	-	828	WP_000136014.1	alpha/beta hydrolase	-
IF748_RS00125	22421..23620	-	1200	WP_000286461.1	NADH-dependent flavin oxidoreductase	-
IF748_RS00130	23716..23808	+	93	WP_001802007.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	52..20624	20572

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174373 WP_072357969.1 NZ_CP062336:19215-19391 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174373 NZ_CP080999:c4147657-4147220 [Mycobacterium malmoense]
GTGACTGGTCGGCGCTTGTCGGTGGACACGAGCGTCGCTGTGCCGTTGCTGGTGGCTTCTCACGAACGCCATCACGCGGT
CGCCGAGTGGGCGCGGGGGCGGTCGCTGAGTCTGAGCAGTCATGCCCTGGCGGAGACGTACTCGGTCCTCACCCGGTTGC
CGGGTGATGCGCGCGTGGCGCCGGCGGATGCGGTCACGCTCATCGATGAGAACTTCGATGAAGTATTGGTTCTGTCGGCG
ACTGCAGCGCGGGGAGCGCACCGGGAACTCGCGGCCAACGGCGTCGCCGGGGGTGCGACGTACGACGGGCTCGTGGCGCT
GGCTGGCCGTGAGCATGGTGCGGTCTTGGTCAGTCGGGATGCGCGGGCGCGGTCGACGTACGAGACGCTCGGAGTTGCCG
TCGAAGTACTTGTCGGTGCGGCTGGGCCCGCTCAGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174373 NZ_CP062336:c19553-19379 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin