Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2370107..2370624 Replicon chromosome
Accession NZ_CP062334
Organism Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF749_RS11680 Protein ID WP_000113262.1
Coordinates 2370358..2370624 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF749_RS11675 Protein ID WP_000584499.1
Coordinates 2370107..2370358 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF749_RS11645 (2365805) 2365805..2366524 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF749_RS11650 (2366521) 2366521..2367252 + 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
IF749_RS11655 (2367349) 2367349..2368599 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF749_RS11660 (2368854) 2368854..2369216 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF749_RS11665 (2369235) 2369235..2369834 + 600 WP_000162813.1 DsbA family protein -
IF749_RS11670 (2369841) 2369841..2369942 + 102 WP_001791744.1 hypothetical protein -
IF749_RS11675 (2370107) 2370107..2370358 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF749_RS11680 (2370358) 2370358..2370624 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF749_RS11685 (2370659) 2370659..2370730 + 72 Protein_2273 hypothetical protein -
IF749_RS11690 (2370919) 2370919..2372469 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF749_RS11695 (2372655) 2372655..2373122 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF749_RS11700 (2373206) 2373206..2373388 + 183 WP_000230294.1 hypothetical protein -
IF749_RS11705 (2373605) 2373605..2374429 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF749_RS11710 (2374662) 2374662..2375198 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174366 WP_000113262.1 NZ_CP062334:2370358-2370624 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174366 NZ_CP080999:c2264389-2264132 [Mycobacterium malmoense]
GTGAGAAGCATCCACTTCGATCCCAATGCCTGGGAGGACTTTCTATTCTGGCTGGGCTCCGACCGCAAGGCGGCCCGTCG
GGTCACCCGCCTGATCGCCGAGGTCCAACGCGATCCTTTCCGTGGCACCGGCAAACCCGAACCACTCAAGGGCGAGCTAT
CGGGTTACTGGTCCCGTCGAATCGACGACCAACATCGGCTTGTGTACCGAGCCGATGGCGACGAAGTCAAAATCCTCAAG
GCCCGATACCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174366 WP_000584499.1 NZ_CP062334:2370107-2370358 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174366 NZ_CP080999:c2264661-2264386 [Mycobacterium malmoense]
ATGAGCATCAGCGCAAGCGAGGCTAGACAACGCCTGTACCCGCTTCTCGCGCAAGTCAATACCGATCACCAACCTGTGCG
CATCACCTCCAAAGCCGGCGACGCGGTGCTCATGTCCGCCGACGACTACGACTCCTGGCAGGAAACGGTCTACCTGCTGC
GCTCACCAAAGAATGCCCAACGACTCATGGAAGCGGTCGCCCGGGACAAGGCCGGGCACTTTGCACTCACCAAGTCCGTC
GACGAGCTGCAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References