Detailed information of TA system TA174364

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2345192..2345376
• Replicon: chromosome
• Accession: NZ_CP062334
• Organism: Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: IF749_RS11545
• Protein ID: WP_072467491.1
• Coordinates: 2345192..2345299 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2345316..2345376 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF749_RS11520	2340565..2341038	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF749_RS11525	2341161..2342372	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF749_RS11530	2342554..2343213	-	660	WP_000831298.1	membrane protein	-
IF749_RS11535	2343273..2344415	-	1143	WP_001176873.1	glycerate kinase	-
IF749_RS11540	2344672..2345058	+	387	WP_000779348.1	flippase GtxA	-
IF749_RS11545	2345192..2345299	+	108	WP_072467491.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2345316..2345376	-	61	-	-	Antitoxin
IF749_RS11550	2345889..2347652	+	1764	WP_001064834.1	ABC transporter ATP-binding protein	-
IF749_RS11555	2347677..2349410	+	1734	WP_000486502.1	ABC transporter ATP-binding protein	-
IF749_RS11560	2349641..2349808	+	168	WP_031866196.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (79-177)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3944.67 Da
• Isoelectric Point: 10.4934

>T174364 WP_072467491.1 NZ_CP062334:2345192-2345299 [Staphylococcus aureus]
IFNLLIDIMTSAISGCLVAFFANWLRTRSNKKGDK

Nucleotide

• Length: 108 bp

>T174364 NZ_CP080999:c2152744-2151914 [Mycobacterium malmoense]
GTGGACTTGGAGTCTCGACCACCGTGGTCGAACAACGCGCTGCGTCGTCTTGGGGCGGCGCTTCGCGATGGAGTCGACCC
GCCGATCGATTGCCCGTCGTACGCAGACGTGATGTTGTGGCACTTCGACCTGGCTGCCGAAGTGCAGGATCAAATCGAGA
GCGGGAGTTGGTCGATCAGGTCGGAGTTGTTGGCGACCAAAGCAGGACGGCTGACGCCGGATTTACAGGTTAGCTCACGC
CCAAAGACCCAAGACACGTTGGTGGAAAAGCTGCAACGGCAGCCCAGCCTGCAACTGAATGCTGTCCAAGACCTCGCTGG
TGTTCGCATTGACGCCGACCTGCTGTTGGGCGAACAGATGAGCCTCGCTCGGGAGATCGCCAGTTACTTCTGTGCGGACG
AGTCAGCCATCCATGATCTGCGCGATGGCACGCACGCTGGTTACCGTGGCGTTCATGTCTGGCTTCGGTTGCCTGCTGGG
CGGGTCGAAATACAGATTCGGACGATTCTTCAAAGCCTGTGGGCGAACCTGTTTGAGAAGCTCGCAGATGAAGTCGGCCG
GGGCATCCGCTACGGCGAACCTGTCGAACCGTCGCCCGGCGTAGACGTAGGACGGATTCAGCGCGCGGTGCAGAGCATGC
AGGAATTCTCGGCAAAGGTGGCAGCTAGCGAAGCGGACTGGCAACAGTGTTCCGAGATCGAAGACCCTGGTCGGCGCGGA
GTCGCGCTCGGAACAGCCGCCATGGACAGGGCGATGTGGGTCGGTTTGGTGGCTTATGCTGCACAGAAGGCTAGTGGTGA
GGCTGAGTCCTCCAAAGGGGAAGATGGGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174364 NZ_CP062334:c2345376-2345316 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin