Detailed information of TA system TA174363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2313834..2314357
• Replicon: chromosome
• Accession: NZ_CP062334
• Organism: Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF749_RS11415
• Protein ID: WP_000074046.1
• Coordinates: 2314091..2314357 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF749_RS11410
• Protein ID: WP_000587615.1
• Coordinates: 2313834..2314091 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF749_RS11390 (2308929)	2308929..2310122	+	1194	WP_000675403.1	MFS transporter	-
IF749_RS11395 (2310346)	2310346..2311095	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF749_RS11400 (2311285)	2311285..2312862	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF749_RS11405 (2313012)	2313012..2313476	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF749_RS11410 (2313834)	2313834..2314091	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF749_RS11415 (2314091)	2314091..2314357	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF749_RS11420 (2314670)	2314670..2315746	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF749_RS11425 (2315994)	2315994..2316656	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF749_RS11430 (2316649)	2316649..2317422	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF749_RS11435 (2317774)	2317774..2318958	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174363 WP_000074046.1 NZ_CP062334:2314091-2314357 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174363 NZ_CP080999:c2067376-2066984 [Mycobacterium malmoense]
GTGAAGCGCTACCTCGTCGACACCCATGTGTGGCTGTGGATGCAGTCCGACCCCGACCGGCTACGCGACGAAGCACGCGA
AATCGTCCAGGACGCCCGCAACAGCGTTCTCCTCTCGGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGGCTCGGCA
AACTCCCGTTGCCCGAAGCGCCGGCCTCCTACCTGCCCGATCGGATGCGCCGTTCCGGAACGTCTCCGCTGCCGGTCGAC
CACGCACACGCGCTGCGAACCGCCGAGCTTCCGGATCACCACCGGGATCCGTTCGACCGGCTCCTCATCGCCCAGGCGCA
GCTGCTCGACCTGACGATCATGACGGCCGACGAACAGCTGTCTGCCTATGACGTCGCGGTCGTCGCGGCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174363 WP_000587615.1 NZ_CP062334:2313834-2314091 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174363 NZ_CP080999:c2067618-2067373 [Mycobacterium malmoense]
ATGACTAAGTCCGCTGCCATCAGGGTCGGCGTCCACGAGGCGAAGACCCGCATGTCGGAGCTGCTGCGGCTGGTCGACAG
CGGGCAGGAGATCGAGATCGCCCGCGGCGGTGAACCCGTGGCCAAGCTGGTGCCGTTTCGCTCCCCAGAGATCCGCCGCT
TGGGCATAGACCACGGCGTCTACGCCGTGCCCGACGATTTCGATGCACCGTTACCCGACGACGTCCTCCACAGCTTCTAC
CGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2