Detailed information of TA system TA174360

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 209674..209854
• Replicon: chromosome
• Accession: NZ_CP062334
• Organism: Staphylococcus aureus strain NAS_NP_164

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF749_RS01405
• Protein ID: WP_001801861.1
• Coordinates: 209759..209854 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	209674..209731 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF749_RS01375	206025..207143	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF749_RS01380	207791..208234	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF749_RS01385	208513..208791	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF749_RS01390	208813..209187	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF749_RS01395	209375..209557	+	183	Protein_241	transposase	-
IF749_RS01400	209535..209636	-	102	WP_001791232.1	hypothetical protein	-
-	209674..209731	+	58	-	-	Antitoxin
IF749_RS01405	209759..209854	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF749_RS01410	210305..210751	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF749_RS01415	211436..211819	+	384	WP_000070811.1	hypothetical protein	-
IF749_RS01420	211830..212006	+	177	WP_000375476.1	hypothetical protein	-
IF749_RS01425	212306..212934	+	629	Protein_247	ImmA/IrrE family metallo-endopeptidase	-
IF749_RS01430	213132..213704	-	573	Protein_248	hypothetical protein	-
IF749_RS01435	213805..214146	-	342	WP_000627548.1	DUF3969 family protein	-
IF749_RS01440	214187..214813	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	188137..217373	29236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174360 WP_001801861.1 NZ_CP062334:c209854-209759 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174360 NZ_CP080999:c605942-605697 [Mycobacterium malmoense]
GTGGCGATCACCGCGTCCGAGGCACGCAAGAACTTATTTCCGTTGATCGAGCAGGTCAACAACGACCGCGTCCCGGTGGA
GATCAACTCCCGCCGGGGTGATGCGGTATTGATCTCGCGCGCCGACTACGAAGCCCTGGAAGAGACCGCGCACCTGTTGC
GGTCCCCCGCCAATGCCCGTCGGCTGCTGGAAAGCCTTACCCAGGCGCAGCGTGGCGAACGCGAAGAGCACACGTTGTCC
CGGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174360 NZ_CP062334:209674-209731 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin