Detailed information of TA system TA174349

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2668224..2668503
• Replicon: chromosome
• Accession: NZ_CP062331
• Organism: Staphylococcus aureus strain NAS_OP_017

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF760_RS13275
• Protein ID: WP_001802298.1
• Coordinates: 2668224..2668328 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2668324..2668503 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF760_RS13245	2663608..2664390	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
IF760_RS13250	2664458..2665315	+	858	WP_000370924.1	HAD family hydrolase	-
IF760_RS13260	2666020..2666112	-	93	WP_001790138.1	hypothetical protein	-
IF760_RS13265	2666401..2667537	+	1137	WP_000115564.1	SAP domain-containing protein	-
IF760_RS13270	2667580..2668063	+	484	Protein_2579	recombinase family protein	-
IF760_RS13275	2668224..2668328	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2668324..2668503	-	180	-	-	Antitoxin
IF760_RS13285	2668828..2669919	-	1092	WP_000495671.1	lytic regulatory protein	-
IF760_RS13290	2670185..2671165	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF760_RS13295	2671167..2671487	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF760_RS13300	2671639..2672304	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174349 WP_001802298.1 NZ_CP062331:2668224-2668328 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174349 NZ_CP080997:2463142-2463720 [Mycolicibacter heraklionensis]
CTGAGGCGGCTCGACCTCGTTGTCGGCCCCAACGGGGCGGGCAAGTCGACCTTTGTTGCCCTCACGCTGGCGCCCCTGCT
GCCGGGGGCCCTGTTCGTCAACGCCGACGAAATCGCCAAGACTCGTTGGCCCGACGAGGTGGCCGCGCACGCCTACGATG
CGGCGCGGCTGGCCGCAAAGACCCGGATGAAACTTATCGAGGCGGGGCGTTCGTTCATCGCCGAGACGGTGTTCTCGCAT
GGATCGAAGATCGACTTGATCCATGGTGCACACGCCCACGGATACACGGTGGTGCTGCATGCGGTGCTCATCCCCGAAGC
GTTGGCGGTCCAGCGCGTGCGGTACCGGGTGGCCGCCGGTGGACATGCCGTTCCCGAGGAGAAGATCCGCGAGCGCTACC
ACCGGGTCTGGCCCCTGGTCGCCGAAGCGATCGGAATCGTCGACGTCGCAACGGTTTACGACAATTCGCGCGTGACCGGG
CCGAAGATTGTGGCGCAGTTCGCGGGGGGCGCCCAGATCGGTGACCCGAGTTGGCCGAGCTGGGCGCCCCCCGCGCTGGT
CACGCGCCGCCATCCCTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT174349 NZ_CP062331:c2668503-2668324 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin