Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2403216..2403733 Replicon chromosome
Accession NZ_CP062331
Organism Staphylococcus aureus strain NAS_OP_017

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF760_RS11890 Protein ID WP_000113262.1
Coordinates 2403467..2403733 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag IF760_RS11885 Protein ID WP_000584502.1
Coordinates 2403216..2403467 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF760_RS11855 (2398917) 2398917..2399636 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF760_RS11860 (2399633) 2399633..2400364 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF760_RS11865 (2400461) 2400461..2401711 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF760_RS11870 (2401966) 2401966..2402325 + 360 WP_000819847.1 DUF4467 domain-containing protein -
IF760_RS11875 (2402344) 2402344..2402943 + 600 WP_000162813.1 DsbA family protein -
IF760_RS11880 (2402950) 2402950..2403051 + 102 WP_001791744.1 hypothetical protein -
IF760_RS11885 (2403216) 2403216..2403467 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF760_RS11890 (2403467) 2403467..2403733 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF760_RS11895 (2403768) 2403768..2403839 + 72 Protein_2313 hypothetical protein -
IF760_RS11900 (2404028) 2404028..2405578 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF760_RS11905 (2405764) 2405764..2406231 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF760_RS11910 (2406315) 2406315..2406497 + 183 WP_000230294.1 hypothetical protein -
IF760_RS11915 (2406714) 2406714..2407538 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF760_RS11920 (2407771) 2407771..2408307 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174347 WP_000113262.1 NZ_CP062331:2403467-2403733 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174347 NZ_CP080997:c1432769-1432569 [Mycolicibacter heraklionensis]
GTGTTGGCGTTCGAGTTCGATCCAGCCAAGAGCGCTGCAAACCTGACCAAGCACGGCATCGACTTCGATGTTGCACAGTC
CATTTGGTCCGACCCCCGCCGCATCGAAGTGCCGGCACGCACGACGGATGAGCCGAGGTGGATGGCGATCGGGCAGATAG
ACGGCCGATGCTGGTCCGCGGTATTGACCTACCCGAGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT174347 WP_000584502.1 NZ_CP062331:2403216-2403467 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174347 NZ_CP080997:c1432515-1432279 [Mycolicibacter heraklionensis]
ATGAAAGCTGACGAGTTCGACGAACGATTCGACAACGGCCAGGACATGGCCGCCGCTCTCGACACCGCACGGGCACGCCG
CCCGGGCGAGCAGCACCGCCGAGTCAACGTCGACTTCCCGGTCTGGATGATCGCCGAACTCGACCGCGAAGCAACCCGAC
TCGGAGTCACCCGCCAGTCGCTCATCAAAGTCTGGATCGCGGAGAAACTTGACCACGGCGGTCACACCGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References