Detailed information of TA system TA174345

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2378201..2378385
• Replicon: chromosome
• Accession: NZ_CP062331
• Organism: Staphylococcus aureus strain NAS_OP_017

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF760_RS11755
• Protein ID: WP_000482650.1
• Coordinates: 2378201..2378308 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2378325..2378385 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF760_RS11730	2373563..2374036	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF760_RS11735	2374159..2375370	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF760_RS11740	2375552..2376211	-	660	WP_000831298.1	membrane protein	-
IF760_RS11745	2376271..2377413	-	1143	WP_001176863.1	glycerate kinase	-
IF760_RS11750	2377681..2378067	+	387	WP_000779358.1	flippase GtxA	-
IF760_RS11755	2378201..2378308	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2378325..2378385	-	61	-	-	Antitoxin
IF760_RS11760	2378936..2380699	+	1764	WP_240021550.1	ABC transporter ATP-binding protein	-
IF760_RS11765	2380724..2382457	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF760_RS11770	2382688..2382855	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174345 WP_000482650.1 NZ_CP062331:2378201-2378308 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174345 NZ_CP080997:c757719-757321 [Mycolicibacter heraklionensis]
ATGCTGTATCTGGACACGTCGGCTCTGGTGAAGCTCGTCCGGCGTGAACCGGAGAGTGATGCGCTCGTCGACTGGCTTGC
CGCACAGCAGCCAACGCCATGGGTGTCCTCAACGCTGATCGAGGCCGAACTGCCTCGCGCCATCCGGCGGGCGGAGCCGT
CGTTGCTGGTCGATGTCCCGGCAACGCTGGCACGGGTCTCCCGCTACGAGGTGAACGAGGTGGTTCGGGCCGCCGCTGCT
GCATTACCCGACCCGACGCTGCGATCCCTGGACGCCATCCATCTGGCGACCGGCCACGCGGTGTTCGGCGCCAGGCTGAC
GGCGTTCGTCGCCTACGACGGACGCCTGCTCGCGGCCGCCGAAGCCATCGGCCTGCCGACCGTTTCCCCGGGTCGCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174345 NZ_CP062331:c2378385-2378325 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin