Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2346362..2346885 Replicon chromosome
Accession NZ_CP062331
Organism Staphylococcus aureus strain NAS_OP_017

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF760_RS11615 Protein ID WP_000074048.1
Coordinates 2346619..2346885 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF760_RS11610 Protein ID WP_000587616.1
Coordinates 2346362..2346619 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF760_RS11590 (2341442) 2341442..2342635 + 1194 WP_000675401.1 MFS transporter -
IF760_RS11595 (2342859) 2342859..2343608 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF760_RS11600 (2343803) 2343803..2345380 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF760_RS11605 (2345548) 2345548..2346003 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF760_RS11610 (2346362) 2346362..2346619 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF760_RS11615 (2346619) 2346619..2346885 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF760_RS11620 (2347240) 2347240..2348316 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF760_RS11625 (2348564) 2348564..2349226 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF760_RS11630 (2349219) 2349219..2349995 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF760_RS11635 (2350391) 2350391..2351578 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174344 WP_000074048.1 NZ_CP062331:2346619-2346885 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174344 NZ_CP080997:719400-719798 [Mycolicibacter heraklionensis]
ATGATCGTCGACACGTCGGCGATCATCGCGATCCTTCGGGATGAAGATGACGCGCCCCGCTACGCCCGGGCCATCGCCGG
GGCGCAATCGCGTCGGCTGTCCGCGGCGGCGTACCTCGAATGTGGGATCGTCTTGGATTCGCAGCGCGATCCGATCATCA
GCAGAGCCTTGGATGAACTCCTCGACGACGCCGGTTTTGTCATCGAGCCGGTCACCGAACGACAAGCCAGGCTCGCCAGG
CAGGCCTACGCGGATTTCGGCAAGGGCAGCAGCCATCCTGCGGGGTTGAACTTCGGTGACTGTCTTTCGTATGCACTGGC
GACGGACCTTCGCGAACCGCTGCTGTGGAAGGGCGACGACTTCGGGTACACCGGAATACGTTCGGCCTGCGACGAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174344 WP_000587616.1 NZ_CP062331:2346362-2346619 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174344 NZ_CP080997:719161-719403 [Mycolicibacter heraklionensis]
ATGGCGTTGAACATCAAAGATCCAGCGGTTCATGAAGCGGTCAAAGAGATCGCCCGGATCACCGGCGAATCCCAGGCGCA
GGCGGTGGCCACCGCGGTGCGCGACCGGCTTGTCCACGTGCAGGCGGACGCCGCCGCCGCGCGGCTACTGGCCATCGGAA
GGCGGACCGCCGCCCGGATGAGCCCGGAAACCAAGCGGCTGGACCACGGCACTCTGCTCTATGACCAGCACGGAATGCCA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References