174336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2716268..2716682 Replicon chromosome
Accession NZ_CP062329
Organism Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF761_RS13400 Protein ID WP_001065046.1
Coordinates 2716268..2716519 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF761_RS13405 Protein ID WP_000028424.1
Coordinates 2716509..2716682 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF761_RS13355 (2711680) 2711680..2712600 + 921 WP_000138475.1 recombinase RecT -
IF761_RS13360 (2712681) 2712681..2713298 + 618 WP_077517322.1 MBL fold metallo-hydrolase -
IF761_RS13365 (2713299) 2713299..2713769 + 471 WP_000610649.1 single-stranded DNA-binding protein -
IF761_RS13370 (2713799) 2713799..2714650 + 852 WP_218702631.1 DnaD domain protein -
IF761_RS13375 (2714657) 2714657..2714875 + 219 WP_000338528.1 hypothetical protein -
IF761_RS13380 (2714884) 2714884..2715289 + 406 Protein_2598 RusA family crossover junction endodeoxyribonuclease -
IF761_RS13385 (2715302) 2715302..2715670 + 369 WP_023604910.1 SA1788 family PVL leukocidin-associated protein -
IF761_RS13390 (2715674) 2715674..2715916 + 243 WP_023604909.1 phi PVL orf 51-like protein -
IF761_RS13395 (2715925) 2715925..2716275 + 351 WP_025176279.1 hypothetical protein -
IF761_RS13400 (2716268) 2716268..2716519 + 252 WP_001065046.1 DUF1024 family protein Toxin
IF761_RS13405 (2716509) 2716509..2716682 + 174 WP_000028424.1 hypothetical protein Antitoxin
IF761_RS13410 (2716683) 2716683..2716835 + 153 WP_016170781.1 hypothetical protein -
IF761_RS13415 (2716965) 2716965..2717126 + 162 WP_000889682.1 hypothetical protein -
IF761_RS13420 (2717141) 2717141..2717674 + 534 WP_023604907.1 dUTPase -
IF761_RS13425 (2717711) 2717711..2717917 + 207 WP_000195794.1 DUF1381 domain-containing protein -
IF761_RS13430 (2717914) 2717914..2718117 + 204 WP_000141180.1 hypothetical protein -
IF761_RS13435 (2718110) 2718110..2718346 + 237 WP_000608275.1 hypothetical protein -
IF761_RS13440 (2718339) 2718339..2718725 + 387 WP_000592202.1 hypothetical protein -
IF761_RS13445 (2718722) 2718722..2718871 + 150 WP_000595265.1 transcriptional activator RinB -
IF761_RS13450 (2718871) 2718871..2719071 + 201 WP_000265043.1 DUF1514 family protein -
IF761_RS13455 (2719099) 2719099..2719515 + 417 WP_000590122.1 hypothetical protein -
IF761_RS13460 (2719747) 2719747..2720046 + 300 WP_000988336.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T174336 WP_001065046.1 NZ_CP062329:2716268-2716519 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T174336 NZ_CP080960:3536791-3537102 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT174336 WP_000028424.1 NZ_CP062329:2716509-2716682 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT174336 NZ_CP080960:3537099-3537545 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References