Detailed information of TA system TA174331

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2565867..2566145
• Replicon: chromosome
• Accession: NZ_CP062329
• Organism: Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF761_RS12570
• Protein ID: WP_001802298.1
• Coordinates: 2565867..2565971 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2565967..2566145 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF761_RS12550	2562664..2563446	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF761_RS12555	2563514..2564371	+	858	WP_000370928.1	HAD family hydrolase	-
IF761_RS12560	2565029..2565187	-	159	WP_001792784.1	hypothetical protein	-
IF761_RS12565	2565180..2565350	-	171	WP_001792292.1	transposase	-
IF761_RS12570	2565867..2565971	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2565967..2566145	-	179	-	-	Antitoxin
IF761_RS12580	2566470..2567561	-	1092	WP_000495681.1	hypothetical protein	-
IF761_RS12585	2567827..2568807	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF761_RS12590	2568809..2569129	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF761_RS12595	2569281..2569946	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174331 WP_001802298.1 NZ_CP062329:2565867-2565971 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174331 NZ_CP080960:2436374-2436592 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT174331 NZ_CP062329:c2566145-2565967 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin