Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2309458..2309975 | Replicon | chromosome |
| Accession | NZ_CP062329 | ||
| Organism | Staphylococcus aureus strain NAS_OP_026 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF761_RS11230 | Protein ID | WP_000113262.1 |
| Coordinates | 2309709..2309975 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF761_RS11225 | Protein ID | WP_000584499.1 |
| Coordinates | 2309458..2309709 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF761_RS11195 (2305156) | 2305156..2305875 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IF761_RS11200 (2305872) | 2305872..2306603 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF761_RS11205 (2306700) | 2306700..2307950 | - | 1251 | WP_001012228.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF761_RS11210 (2308205) | 2308205..2308567 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF761_RS11215 (2308586) | 2308586..2309185 | + | 600 | WP_000162803.1 | DsbA family protein | - |
| IF761_RS11220 (2309213) | 2309213..2309293 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| IF761_RS11225 (2309458) | 2309458..2309709 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF761_RS11230 (2309709) | 2309709..2309975 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF761_RS11235 (2310010) | 2310010..2310081 | + | 72 | WP_223200558.1 | hypothetical protein | - |
| IF761_RS11240 (2310269) | 2310269..2311822 | + | 1554 | WP_000727769.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF761_RS11245 (2312008) | 2312008..2312475 | + | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IF761_RS11250 (2312562) | 2312562..2312744 | + | 183 | WP_000079142.1 | hypothetical protein | - |
| IF761_RS11255 (2312961) | 2312961..2313785 | + | 825 | WP_240029347.1 | formate/nitrite transporter family protein | - |
| IF761_RS11260 (2314019) | 2314019..2314555 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174329 WP_000113262.1 NZ_CP062329:2309709-2309975 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174329 NZ_CP080958:c4658414-4658028 [Citrobacter amalonaticus]
ATGCAAAAGGGACCCGTGTTGTTCGATACCAATATCCTGATTGATTTATTTAGCGGGCGCCAGGAAGCACAGCAAGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCTTGATTACCTGGATGGAAGTCATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACGCGTGTGGCATTGAGTGCGTTCAATATCATCGGTGTATCACTGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAGGCCGGACGATAA
ATGCAAAAGGGACCCGTGTTGTTCGATACCAATATCCTGATTGATTTATTTAGCGGGCGCCAGGAAGCACAGCAAGTACT
GGAAGCGTATCCGCCGCAGAATGCCATCAGCTTGATTACCTGGATGGAAGTCATGGTGGGGGCAAAAAAATACCATCAGG
AATATCGTACGCGTGTGGCATTGAGTGCGTTCAATATCATCGGTGTATCACTGGAAATTGCTGAGCGAAGCGTGAATCTC
AGGCAGGAATATGGGATGAAACTTCCGGACGCGATCATTCTGGCTACCGCGCAGATTCATCGGTTTGCGCTTGTGACGCG
CAACACCAGAGATTTCGCGGGGATACCTGGCGTCATTACGCCTTATCAGTTGCAGGCCGGACGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174329 WP_000584499.1 NZ_CP062329:2309458-2309709 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174329 NZ_CP080958:c4658656-4658414 [Citrobacter amalonaticus]
ATAATGGCTGGAATGGACATGGGCAGAATATTACTCGACTTATCCGATGAGGTGATCAAACGCCTTGACGATCTCAAGCA
GCAGCGGAATCTGCCCCGTGCGGAGTTGCTGCGCGAAGCGGTTGAACAGTACCTTGAAAGGCAAGGCCAGGCTGAAACCA
CAATTTCCAATGCGCTGGGGCTCTGGCAGGGTTGTGAGGAAGACGGCGTTGAGTATCAGAGGACGCTGCGCGAGGAATGG
TAA
ATAATGGCTGGAATGGACATGGGCAGAATATTACTCGACTTATCCGATGAGGTGATCAAACGCCTTGACGATCTCAAGCA
GCAGCGGAATCTGCCCCGTGCGGAGTTGCTGCGCGAAGCGGTTGAACAGTACCTTGAAAGGCAAGGCCAGGCTGAAACCA
CAATTTCCAATGCGCTGGGGCTCTGGCAGGGTTGTGAGGAAGACGGCGTTGAGTATCAGAGGACGCTGCGCGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|