Detailed information of TA system TA174327

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2284419..2284603
• Replicon: chromosome
• Accession: NZ_CP062329
• Organism: Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF761_RS11095
• Protein ID: WP_000482650.1
• Coordinates: 2284419..2284526 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2284543..2284603 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF761_RS11070	2279791..2280264	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF761_RS11075	2280387..2281598	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF761_RS11080	2281780..2282439	-	660	WP_000831298.1	membrane protein	-
IF761_RS11085	2282499..2283641	-	1143	WP_001176863.1	glycerate kinase	-
IF761_RS11090	2283899..2284285	+	387	WP_000779358.1	flippase GtxA	-
IF761_RS11095	2284419..2284526	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2284543..2284603	-	61	-	-	Antitoxin
IF761_RS11100	2285174..2286937	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF761_RS11105	2286962..2288695	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF761_RS11110	2288926..2289093	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174327 WP_000482650.1 NZ_CP062329:2284419-2284526 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174327 NZ_CP080958:c4015652-4015245 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCGATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTATTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGACTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCAGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGGGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174327 NZ_CP062329:c2284603-2284543 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin