174326

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2252899..2253422 Replicon chromosome
Accession NZ_CP062329
Organism Staphylococcus aureus strain NAS_OP_026

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag IF761_RS10955 Protein ID WP_000074043.1
Coordinates 2253156..2253422 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag IF761_RS10950 Protein ID WP_000587618.1
Coordinates 2252899..2253156 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF761_RS10935 (2249394) 2249394..2250143 - 750 WP_000072441.1 CPBP family lipoprotein N-acylation protein LnsB -
IF761_RS10940 (2250339) 2250339..2251916 + 1578 WP_000143508.1 FMN-binding glutamate synthase family protein -
IF761_RS10945 (2252084) 2252084..2252539 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF761_RS10950 (2252899) 2252899..2253156 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF761_RS10955 (2253156) 2253156..2253422 + 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
IF761_RS10960 (2253778) 2253778..2254854 + 1077 WP_001076665.1 M42 family metallopeptidase -
IF761_RS10965 (2255102) 2255102..2255764 + 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
IF761_RS10970 (2255757) 2255757..2256533 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF761_RS10975 (2256929) 2256929..2258116 + 1188 WP_000026187.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T174326 WP_000074043.1 NZ_CP062329:2253156-2253422 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T174326 NZ_CP080958:c2783209-2783106 [Citrobacter amalonaticus]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT174326 WP_000587618.1 NZ_CP062329:2252899-2253156 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174326 NZ_CP080958:2783102-2783249 [Citrobacter amalonaticus]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References