Detailed information of TA system TA174315

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2289192..2289376
• Replicon: chromosome
• Accession: NZ_CP062326
• Organism: Staphylococcus aureus strain NAS_OP_043

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF764_RS11140
• Protein ID: WP_000482647.1
• Coordinates: 2289192..2289299 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2289316..2289376 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF764_RS11115	2284556..2285029	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
IF764_RS11120	2285152..2286363	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
IF764_RS11125	2286543..2287202	-	660	WP_000831298.1	membrane protein	-
IF764_RS11130	2287262..2288404	-	1143	WP_001176860.1	glycerate kinase	-
IF764_RS11135	2288672..2289058	+	387	WP_000779354.1	flippase GtxA	-
IF764_RS11140	2289192..2289299	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2289316..2289376	-	61	-	-	Antitoxin
IF764_RS11145	2289326..2289493	+	168	WP_000301894.1	hypothetical protein	-
IF764_RS11150	2289871..2291610	+	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
IF764_RS11155	2291659..2293392	+	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
IF764_RS11160	2293623..2293790	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174315 WP_000482647.1 NZ_CP062326:2289192-2289299 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174315 NZ_CP080770:876251-876571 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Nucleotide

• Length: 61 bp

>AT174315 NZ_CP062326:c2289376-2289316 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin