Detailed information of TA system TA174311

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 20057..20364
• Replicon: chromosome
• Accession: NZ_CP062326
• Organism: Staphylococcus aureus strain NAS_OP_043

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF764_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20057..20233 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	20223..20364 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF764_RS00090	17841..17993	+	153	WP_001153681.1	hypothetical protein	-
IF764_RS00095	18148..19277	+	1130	WP_098686295.1	IS3 family transposase	-
IF764_RS00100	19281..19553	+	273	WP_064138970.1	hypothetical protein	-
IF764_RS00105	19611..19907	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
IF764_RS00110	20057..20233	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20223..20364	-	142	-	-	Antitoxin
IF764_RS00120	20445..20699	+	255	WP_000611512.1	phage holin	-
IF764_RS00125	20711..21466	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF764_RS00130	21657..22148	+	492	WP_000919350.1	staphylokinase	-
IF764_RS00135	22798..23133	+	336	Protein_26	SH3 domain-containing protein	-
IF764_RS00140	23228..23677	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
IF764_RS00145	24362..24712	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF764_RS00150	24765..25025	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..24712	24711
	-	flank	IS/Tn	-	-	18148..18429	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174311 WP_011447039.1 NZ_CP062326:20057-20233 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174311 NZ_CP080764:420130-420480 [Aneurinibacillus thermoaerophilus]
GTGATCGTGAAGCGTGGCGACGTATATTTTGCGGATTTATCCCCTGTTGTCGGATCGGAGCAGGGCGGAGTCCGGCCTGT
GCTGGTTATACAGAATGATATAGGAAACCGCTTCAGTCCGACAGTAATCGTCGCAGCCATTACGGCCCAAATCCAAAAAG
CTAAGTTGCCTACCCATGTAGAAATTGATGCAAAGACATACGCATTTGACCGTGATTCTGTTATCCTGCTTGAGCAGATA
CGGACGATTGATAAACAGAGATTAACGGATAAGATCACACACCTTGATGAAGAGATGATGGAGCGAGTAAATGAAGCTCT
TCAGATTAGTTTGGGACTTATTGACTTTTAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT174311 NZ_CP062326:c20364-20223 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin