Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2449252..2449769 Replicon chromosome
Accession NZ_CP062324
Organism Staphylococcus aureus strain NAS_OP_063

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF767_RS12170 Protein ID WP_000113262.1
Coordinates 2449503..2449769 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag IF767_RS12165 Protein ID WP_000584502.1
Coordinates 2449252..2449503 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF767_RS12135 (2444953) 2444953..2445672 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF767_RS12140 (2445669) 2445669..2446400 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF767_RS12145 (2446497) 2446497..2447747 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF767_RS12150 (2448002) 2448002..2448361 + 360 WP_000819847.1 DUF4467 domain-containing protein -
IF767_RS12155 (2448380) 2448380..2448979 + 600 WP_000162813.1 DsbA family protein -
IF767_RS12160 (2448986) 2448986..2449087 + 102 WP_001791744.1 hypothetical protein -
IF767_RS12165 (2449252) 2449252..2449503 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF767_RS12170 (2449503) 2449503..2449769 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF767_RS12175 (2449804) 2449804..2449875 + 72 Protein_2370 hypothetical protein -
IF767_RS12180 (2450064) 2450064..2451614 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF767_RS12185 (2451800) 2451800..2452267 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF767_RS12190 (2452351) 2452351..2452533 + 183 WP_000230294.1 hypothetical protein -
IF767_RS12195 (2452750) 2452750..2453574 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF767_RS12200 (2453807) 2453807..2454343 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174301 WP_000113262.1 NZ_CP062324:2449503-2449769 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174301 NZ_CP080759:592750-592866 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT174301 WP_000584502.1 NZ_CP062324:2449252-2449503 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174301 NZ_CP080759:c592982-592777 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References