Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2424237..2424421 Replicon chromosome
Accession NZ_CP062324
Organism Staphylococcus aureus strain NAS_OP_063

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag IF767_RS12035 Protein ID WP_000482650.1
Coordinates 2424237..2424344 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2424361..2424421 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF767_RS12010 2419599..2420072 + 474 WP_000456489.1 GyrI-like domain-containing protein -
IF767_RS12015 2420195..2421406 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF767_RS12020 2421588..2422247 - 660 WP_000831298.1 membrane protein -
IF767_RS12025 2422307..2423449 - 1143 WP_001176863.1 glycerate kinase -
IF767_RS12030 2423717..2424103 + 387 WP_000779358.1 flippase GtxA -
IF767_RS12035 2424237..2424344 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2424361..2424421 - 61 - - Antitoxin
IF767_RS12040 2424972..2426735 + 1764 WP_240029405.1 ABC transporter ATP-binding protein -
IF767_RS12045 2426760..2428493 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
IF767_RS12050 2428724..2428891 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T174299 WP_000482650.1 NZ_CP062324:2424237-2424344 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174299 NZ_CP080759:c335890-335795 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 61 bp

>AT174299 NZ_CP062324:c2424421-2424361 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References