Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2392398..2392921 Replicon chromosome
Accession NZ_CP062324
Organism Staphylococcus aureus strain NAS_OP_063

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF767_RS11895 Protein ID WP_000074048.1
Coordinates 2392655..2392921 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF767_RS11890 Protein ID WP_000587616.1
Coordinates 2392398..2392655 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF767_RS11865 (2387478) 2387478..2388671 + 1194 WP_000675401.1 MFS transporter -
IF767_RS11870 (2388895) 2388895..2389644 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF767_RS11875 (2389839) 2389839..2391416 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF767_RS11880 (2391584) 2391584..2392039 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF767_RS11885 (2392098) 2392098..2392292 + 195 WP_001790145.1 hypothetical protein -
IF767_RS11890 (2392398) 2392398..2392655 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF767_RS11895 (2392655) 2392655..2392921 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF767_RS11900 (2393276) 2393276..2394352 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF767_RS11905 (2394600) 2394600..2395262 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF767_RS11910 (2395255) 2395255..2396031 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF767_RS11915 (2396427) 2396427..2397614 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174298 WP_000074048.1 NZ_CP062324:2392655-2392921 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174298 NZ_CP080636:1277893-1278279 [Acinetobacter lwoffii]
ATGGATAATCGTTGCTTCAAGCTGAAACGCAGTCTGTGTGCATTGGCGTTTCAGCTTTTTATTTTTGCACTGCTGATGTA
TCTGTTGTATCAGTTATTACCGATTGCACTTTGGGCAGTGTGCGCTGTCATAGGCTTGGTGATTTATCAGCTGTTTTACC
GCAAGACACCACAGATTGAACAGTTTGAATATCTGGATGGACGTGAATGGTCATTGACCGCTAAAGCACGATCAACCCGT
CGGGTATGTATTAGTCACGTGATTGATCATCAGGCGTATATTGTGGTGTATTTCCAGCATGCCAAGGCGCGACCTCTGCT
GATCTGGTGTGATCAATTGCCCTTCAAACAATGGAAGTCCTTAAAATTATTGACTAAATTAATTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174298 WP_000587616.1 NZ_CP062324:2392398-2392655 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174298 NZ_CP080636:1277643-1277900 [Acinetobacter lwoffii]
ATGACTGATGACATCAGCTTAGAAGAGCGCAAAGTGATTTATCGTGCGCGTCGTGGTCTAAAAGAACTGGATGTATATTT
TGATCCCTACGTAAAAAACCATTACCTGAATGCTGAGCCTTTCGAAAAACAGATGTTTGCAGAACTGGTTGAGCAGGAAG
ACCCGGATTTGCTGGACTGGTTTATGGAAGTGTCTGAGCCGCCGCGTCCTGAACTAAAAGATTTTATCAAGAAGCTTAAA
TTTTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References