Detailed information of TA system TA174284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2373342..2373859
• Replicon: chromosome
• Accession: NZ_CP062322
• Organism: Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: IF768_RS11690
• Protein ID: WP_000113262.1
• Coordinates: 2373593..2373859 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF768_RS11685
• Protein ID: WP_000584499.1
• Coordinates: 2373342..2373593 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF768_RS11655 (2369040)	2369040..2369759	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF768_RS11660 (2369756)	2369756..2370487	+	732	WP_000615470.1	amino acid ABC transporter ATP-binding protein	-
IF768_RS11665 (2370584)	2370584..2371834	-	1251	WP_001012222.1	FemA/FemB family glycyltransferase FmhA	-
IF768_RS11670 (2372089)	2372089..2372451	+	363	WP_000819843.1	DUF4467 domain-containing protein	-
IF768_RS11675 (2372470)	2372470..2373069	+	600	WP_000162813.1	DsbA family protein	-
IF768_RS11680 (2373076)	2373076..2373177	+	102	WP_001791744.1	hypothetical protein	-
IF768_RS11685 (2373342)	2373342..2373593	+	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF768_RS11690 (2373593)	2373593..2373859	+	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
IF768_RS11695 (2373894)	2373894..2373965	+	72	Protein_2273	hypothetical protein	-
IF768_RS11700 (2374154)	2374154..2375704	+	1551	WP_000727763.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF768_RS11705 (2375890)	2375890..2376357	+	468	WP_000153344.1	SRPBCC domain-containing protein	-
IF768_RS11710 (2376441)	2376441..2376623	+	183	WP_000230294.1	hypothetical protein	-
IF768_RS11715 (2376840)	2376840..2377664	+	825	WP_000572040.1	formate/nitrite transporter family protein	-
IF768_RS11720 (2377897)	2377897..2378433	+	537	WP_000169317.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T174284 WP_000113262.1 NZ_CP062322:2373593-2373859 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174284 NZ_CP080627:c806449-806150 [Halomonas qaidamensis]
ATGCCCACTTTCCATATCACGCTGAGAGCAAGAGACGATTTAAAAAATATCGGCCGCTATACAGAGTGGCAATGGGGCAA
GAACCAACGAAATACCTATTTGAAGAATTTTGAAAAACGGTTTCACTGGCTCGCAGAAAATCCCCAGCTGGGAAAGCACC
GCTCGGATGTTAGCGAGGGTTATTACAGCTACCCTCAGGGCCAGCACGTTATCTTTTATCTAATCGGCCAGGAATGTATT
GAAATCATTGGCATTCCTCACAAAGAGATGGATATCGTTTCTTATTTTCTGCCTGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174284 WP_000584499.1 NZ_CP062322:2373342-2373593 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174284 NZ_CP080627:c806697-806449 [Halomonas qaidamensis]
ATGGCTACAACCAGTCTTAGCTTAGGGGAGCACTGGGAAGTCTTTATCAGAAACGAGGTCGCCAGCGGCCGCTATGGCTC
CGCCAGTGAGGTTGTGCGTGATGCGTTACGTGCAATGGAAGAGCGCAAAAGCAAACTTGAAGCGCTTCGCACTCACTTAG
CTCAAGGTGCAGAGCAAGCGAGAGCAGGTGAATTCGTGGATGATTTTTCGATGGATGCCCTAATCAACGACTTGGATAGC
GAGGCTTGA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E

Antitoxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7BWF
• PDB: 6L8E
• AlphaFold DB: T1YB60