Detailed information of TA system TA174281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2317072..2317595
• Replicon: chromosome
• Accession: NZ_CP062322
• Organism: Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF768_RS11425
• Protein ID: WP_000074046.1
• Coordinates: 2317329..2317595 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF768_RS11420
• Protein ID: WP_000587615.1
• Coordinates: 2317072..2317329 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF768_RS11400 (2312167)	2312167..2313360	+	1194	WP_000675403.1	MFS transporter	-
IF768_RS11405 (2313584)	2313584..2314333	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF768_RS11410 (2314523)	2314523..2316100	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF768_RS11415 (2316250)	2316250..2316714	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF768_RS11420 (2317072)	2317072..2317329	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF768_RS11425 (2317329)	2317329..2317595	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF768_RS11430 (2317908)	2317908..2318984	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF768_RS11435 (2319232)	2319232..2319894	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF768_RS11440 (2319887)	2319887..2320660	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF768_RS11445 (2321012)	2321012..2322196	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174281 WP_000074046.1 NZ_CP062322:2317329-2317595 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174281 NZ_CP080627:707570-707824 [Halomonas qaidamensis]
ATGAAAATTGTATCTTTTACAGAGGCAAGAAATAGTTTGAAAGCAGTATTAGATTCCGTTGTTAATGACGCGGATACAGC
GGTGATTACTCGCCGTGATTCGGAAGATGCTGTTGTTATGTCGCTAGACTACTACAACAGTCTGATGGAAACGGTGCACT
TACTGCGCTCACCGGCGAATGCTGAGCATTTGAATCGCTCAATTGAACAGTTCAAAGCAGGTAAGGTAACCCATAGAGAC
TTAATGGATGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174281 WP_000587615.1 NZ_CP062322:2317072-2317329 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174281 NZ_CP080627:707817-708080 [Halomonas qaidamensis]
ATGAGTAGTCGTTTACTGTCATGGACTGACGAATCCTGGAGCGATTACCTGTATTGGCAAACCCAGGACAAAAAAACGCT
GAAACGAATAAACAAGCTTATAAACGACGCTAGACGCTCACCCTTTGAAGGTATTGGTAAACCAGAGCCGTTAAAGGAAA
ACTTAGCTGGTTTTTGGTCGCGACGTATAGATGATACGAATCGATTAGTCTACGCAGTTGATGATAATGCGATTACGATC
ATTTCGTGTCGTTATCACTATTAG

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2