Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1164275..1164698 Replicon chromosome
Accession NZ_CP062322
Organism Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF768_RS05810 Protein ID WP_086097839.1
Coordinates 1164447..1164698 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF768_RS05805 Protein ID WP_086097840.1
Coordinates 1164275..1164457 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF768_RS05765 (1159291) 1159291..1160697 - 1407 WP_064266702.1 phage portal protein -
IF768_RS05770 (1160716) 1160716..1161981 - 1266 WP_015978295.1 PBSX family phage terminase large subunit -
IF768_RS05775 (1161965) 1161965..1162345 - 381 WP_015977668.1 hypothetical protein -
IF768_RS05780 (1162692) 1162692..1163093 - 402 WP_000286968.1 hypothetical protein -
IF768_RS05785 (1163094) 1163094..1163267 - 174 WP_240024824.1 transcriptional activator RinB -
IF768_RS05790 (1163264) 1163264..1163470 - 207 WP_033859700.1 DUF1381 domain-containing protein -
IF768_RS05795 (1163467) 1163467..1163709 - 243 WP_000028780.1 hypothetical protein -
IF768_RS05800 (1163746) 1163746..1164282 - 537 WP_000185680.1 dUTPase -
IF768_RS05805 (1164275) 1164275..1164457 - 183 WP_086097840.1 hypothetical protein Antitoxin
IF768_RS05810 (1164447) 1164447..1164698 - 252 WP_086097839.1 DUF1024 family protein Toxin
IF768_RS05815 (1164691) 1164691..1164966 - 276 WP_072368557.1 hypothetical protein -
IF768_RS05820 (1164966) 1164966..1165370 - 405 WP_015978309.1 hypothetical protein -
IF768_RS05825 (1165384) 1165384..1165626 - 243 WP_015978343.1 SAV1978 family virulence-associated passenger protein -
IF768_RS05830 (1165630) 1165630..1165998 - 369 WP_015978336.1 SA1788 family PVL leukocidin-associated protein -
IF768_RS05835 (1165999) 1165999..1166184 - 186 WP_015978346.1 DUF3113 family protein -
IF768_RS05840 (1166189) 1166189..1166593 - 405 WP_021758092.1 DUF1064 domain-containing protein -
IF768_RS05845 (1166604) 1166604..1166825 - 222 WP_072498364.1 DUF3269 family protein -
IF768_RS05850 (1166838) 1166838..1166999 - 162 WP_000237153.1 hypothetical protein -
IF768_RS05855 (1166993) 1166993..1167772 - 780 WP_240024825.1 ATP-binding protein -
IF768_RS05860 (1167782) 1167782..1168552 - 771 WP_015977947.1 conserved phage C-terminal domain-containing protein -
IF768_RS05865 (1168617) 1168617..1169372 + 756 WP_000276234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 1131061..1211393 80332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9527.44 Da        Isoelectric Point: 3.7128

>T174278 WP_086097839.1 NZ_CP062322:c1164698-1164447 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDIYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T174278 NZ_CP080624:3238468-3238881 [Acidiferrobacter thiooxydans]
ATGAGCGCATCGCTGGCGTATTTACTGGACACCAATACCCTGTCCGATCTTGTCCGCAATCCGCAAGGTGTAGTAGCAGC
ACAGATCACCAAGGCAGGCGAGGATACTGTCTGCACCAGCATCGTCGTGGCCGCAGAACTCCGCTATGGCGCAACCAAGT
CAAACTCTGCAAAACTTGCAGAGCGCATTGACCTGATCTGCTCAGCACTGGAAATCCTGCCGCTGGAAATACCCGCCGAC
CACCGGTATGCATTAGTGCGCCACCACCTCTCACGCCAGGGGACGCCCATTGGGCCAAATGACCTACTGATTGCTGCACA
CGCTCTCGCAAGGGGCCTTACCGTTGTAACCGCCAATGTCCGAGAATTCTCCCGGGTGCCAGAGCTGAAGGTGGAGAACT
GGCTACAGGCATAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6793.71 Da        Isoelectric Point: 4.4421

>AT174278 WP_086097840.1 NZ_CP062322:c1164457-1164275 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDIHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT174278 NZ_CP080624:3238229-3238471 [Acidiferrobacter thiooxydans]
ATGTCAACTTCTGAACGCCACGTACGCCTCTTTCGCAACGGGCGCAACCAGGCACTACGCATCCCTCGCGAGCTTGAGTT
GGAGGGCGAAGAAGCCCTCATCTACAAGGAAGGTGACCGGTTGATCGTGGAGCCGATTCATAAAGGGAGGCTGCTGGCGC
TGCTAGCCTCCCTGGATCCCTTAACTGAACCCTTTCCCAATATCGATGACGACCTGCCTCCACTGGATGACGTACAGCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References