Detailed information of TA system TA174276

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 167453..167633
• Replicon: chromosome
• Accession: NZ_CP062322
• Organism: Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF768_RS01055
• Protein ID: WP_001801861.1
• Coordinates: 167538..167633 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	167453..167510 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF768_RS01025	163804..164922	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF768_RS01030	165570..166013	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF768_RS01035	166241..166570	+	330	WP_223294405.1	DUF1433 domain-containing protein	-
IF768_RS01040	166592..166966	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF768_RS01045	167154..167336	+	183	Protein_170	transposase	-
IF768_RS01050	167314..167415	-	102	WP_001791232.1	hypothetical protein	-
-	167453..167510	+	58	-	-	Antitoxin
IF768_RS01055	167538..167633	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF768_RS01060	168084..168530	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF768_RS01065	169215..169598	+	384	WP_000070811.1	hypothetical protein	-
IF768_RS01070	169609..169785	+	177	WP_000375476.1	hypothetical protein	-
IF768_RS01075	170085..170713	+	629	Protein_176	ImmA/IrrE family metallo-endopeptidase	-
IF768_RS01080	170911..171483	-	573	Protein_177	hypothetical protein	-
IF768_RS01085	171584..171925	-	342	WP_000627548.1	DUF3969 family protein	-
IF768_RS01090	171966..172592	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	145916..175152	29236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174276 WP_001801861.1 NZ_CP062322:c167633-167538 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174276 NZ_CP080624:c1707790-1707413 [Acidiferrobacter thiooxydans]
ATGGCCGGCAAAGAAAAACCACTCTTCTGGATCGGAAGCAGCAAAAAAGACCTAGTGGGACTTCCCGTCGGAGTGCGGAA
GTTCTTCGGCCATGCCTTGGATTTCGCCCAACGTGGGGATCGGCATGATGCGGCGAAGGTGCTCAAGGGTTTTGGTGGCG
CAGGCGTCCTAGAGGTCGTCGAGGATGACGCCGACGGAACCTATCGGGCCGTTTATACCGTGAGGTTCGAGGAGGCCGTG
TTTGTTCTACACTGTTTTCAAAAGAAGAGTAAAAGCGGAATCGCCACGCCGAAAGAGGACATGAACATTATTCGCGACCG
GCTCAAGATCGCTGAAGCATTCGCAAAGGAGTTACGCCATGGCAAAACGGGTCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174276 NZ_CP062322:167453-167510 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin