Detailed information of TA system TA174274

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 20153..20460
• Replicon: chromosome
• Accession: NZ_CP062322
• Organism: Staphylococcus aureus strain NAS_OP_071

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF768_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20153..20329 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	20319..20460 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF768_RS00090	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF768_RS00095	18039..18326	+	288	WP_001262621.1	hypothetical protein	-
IF768_RS00100	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF768_RS00105	19168..19950	+	783	WP_000034846.1	staphylococcal enterotoxin type P	-
IF768_RS00110	20153..20329	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20319..20460	-	142	-	-	Antitoxin
IF768_RS00120	20541..20795	+	255	WP_000611512.1	phage holin	-
IF768_RS00125	20807..21562	+	756	WP_002955266.1	CHAP domain-containing protein	-
IF768_RS00130	21753..22244	+	492	WP_000920042.1	staphylokinase	-
IF768_RS00135	22893..23228	+	336	Protein_26	SH3 domain-containing protein	-
IF768_RS00140	23739..24089	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF768_RS00145	24142..24402	-	261	WP_001791826.1	hypothetical protein	-
IF768_RS00150	24713..24892	-	180	WP_000669791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / scn	1..24089	24088

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174274 WP_011447039.1 NZ_CP062322:20153-20329 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174274 NZ_CP080624:1621304-1621600 [Acidiferrobacter thiooxydans]
GTGATTGAGGTCCGCAAAACAGATGTTTATGTACGCTGGCTCGACACCCTGCGCGACGAGCGGGCCCGGGCACGCGTTCT
GGCGCGCATCGAACGTCTGCTTACCGGCAATGCGGGTGATGTACGGCCGGTTGGCGGAGGCGTGTCGGAACTGCGTATTG
ATTATGGCCCCGGTTATCGGGTGTATTTCGTGCGTCGGGGTCAGGCGCTCGTAATCCTGCTCGCCGGCGGCGACAAGGGG
TCGCAAAAGGCCGATATTCGCAGGGCTTTGATATTAGCGAGGAATCTTTCCTCTTAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT174274 NZ_CP062322:c20460-20319 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin