Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2193470..2193993 Replicon chromosome
Accession NZ_CP062320
Organism Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF771_RS11160 Protein ID WP_000074048.1
Coordinates 2193470..2193736 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF771_RS11165 Protein ID WP_000587616.1
Coordinates 2193736..2193993 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF771_RS11140 (2188777) 2188777..2189964 - 1188 WP_000026194.1 MFS transporter -
IF771_RS11145 (2190360) 2190360..2191136 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF771_RS11150 (2191129) 2191129..2191791 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF771_RS11155 (2192039) 2192039..2193115 - 1077 WP_001076671.1 M42 family metallopeptidase -
IF771_RS11160 (2193470) 2193470..2193736 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF771_RS11165 (2193736) 2193736..2193993 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF771_RS11170 (2194099) 2194099..2194293 - 195 WP_001790145.1 hypothetical protein -
IF771_RS11175 (2194352) 2194352..2194807 + 456 WP_000732082.1 DUF1307 domain-containing protein -
IF771_RS11180 (2194975) 2194975..2196552 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF771_RS11185 (2196747) 2196747..2197496 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF771_RS11190 (2197720) 2197720..2198913 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174270 WP_000074048.1 NZ_CP062320:c2193736-2193470 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174270 NZ_CP080620:4285925-4286323 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174270 WP_000587616.1 NZ_CP062320:c2193993-2193736 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174270 NZ_CP080620:4285629-4285922 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References