Detailed information of TA system TA174268

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2161971..2162155
• Replicon: chromosome
• Accession: NZ_CP062320
• Organism: Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF771_RS11020
• Protein ID: WP_000482650.1
• Coordinates: 2162048..2162155 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2161971..2162031 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF771_RS11005	2157501..2157668	-	168	WP_001790576.1	hypothetical protein	-
IF771_RS11010	2157899..2159632	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF771_RS11015	2159657..2161420	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2161971..2162031	+	61	-	-	Antitoxin
IF771_RS11020	2162048..2162155	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF771_RS11025	2162288..2162674	-	387	WP_000779358.1	flippase GtxA	-
IF771_RS11030	2162942..2164084	+	1143	WP_001176863.1	glycerate kinase	-
IF771_RS11035	2164144..2164803	+	660	WP_000831298.1	membrane protein	-
IF771_RS11040	2164985..2166196	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF771_RS11045	2166319..2166792	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174268 WP_000482650.1 NZ_CP062320:c2162155-2162048 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174268 NZ_CP080620:c4219225-4218974 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174268 NZ_CP062320:2161971-2162031 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin