Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2136623..2137140 Replicon chromosome
Accession NZ_CP062320
Organism Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF771_RS10885 Protein ID WP_000113262.1
Coordinates 2136623..2136889 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag IF771_RS10890 Protein ID WP_000584502.1
Coordinates 2136889..2137140 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF771_RS10855 (2132049) 2132049..2132585 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
IF771_RS10860 (2132818) 2132818..2133642 - 825 WP_000572040.1 formate/nitrite transporter family protein -
IF771_RS10865 (2133859) 2133859..2134041 - 183 WP_000230294.1 hypothetical protein -
IF771_RS10870 (2134125) 2134125..2134592 - 468 WP_000153344.1 SRPBCC domain-containing protein -
IF771_RS10875 (2134778) 2134778..2136328 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF771_RS10880 (2136517) 2136517..2136588 - 72 Protein_2097 hypothetical protein -
IF771_RS10885 (2136623) 2136623..2136889 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF771_RS10890 (2136889) 2136889..2137140 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF771_RS10895 (2137305) 2137305..2137406 - 102 WP_001791744.1 hypothetical protein -
IF771_RS10900 (2137413) 2137413..2138012 - 600 WP_000162813.1 DsbA family protein -
IF771_RS10905 (2138031) 2138031..2138390 - 360 WP_000819847.1 DUF4467 domain-containing protein -
IF771_RS10910 (2138645) 2138645..2139895 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF771_RS10915 (2139992) 2139992..2140723 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF771_RS10920 (2140720) 2140720..2141439 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174267 WP_000113262.1 NZ_CP062320:c2136889-2136623 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174267 NZ_CP080620:c4218977-4218723 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT174267 WP_000584502.1 NZ_CP062320:c2137140-2136889 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174267 NZ_CP080620:c4219225-4218974 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References