Detailed information of TA system TA174266

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1871913..1872130
• Replicon: chromosome
• Accession: NZ_CP062320
• Organism: Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF771_RS09500
• Protein ID: WP_001802298.1
• Coordinates: 1872026..1872130 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1871913..1871968 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF771_RS09475	1868050..1868715	-	666	WP_001024094.1	SDR family oxidoreductase	-
IF771_RS09480	1868867..1869187	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF771_RS09485	1869189..1870169	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF771_RS09490	1870435..1871526	+	1092	WP_000495671.1	lytic regulatory protein	-
-	1871913..1871968	+	56	-	-	Antitoxin
IF771_RS09500	1872026..1872130	-	105	WP_001802298.1	hypothetical protein	Toxin
IF771_RS09505	1872291..1872774	-	484	Protein_1831	recombinase family protein	-
IF771_RS09510	1872817..1873953	-	1137	WP_000115564.1	SAP domain-containing protein	-
IF771_RS09515	1874242..1874334	+	93	WP_001790138.1	hypothetical protein	-
IF771_RS09525	1875039..1875896	-	858	WP_000370924.1	HAD family hydrolase	-
IF771_RS09530	1875964..1876746	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174266 WP_001802298.1 NZ_CP062320:c1872130-1872026 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174266 NZ_CP080620:4207081-4207455 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT174266 NZ_CP062320:1871913-1871968 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin