Detailed information of TA system TA174259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1536315..1536497
• Replicon: chromosome
• Accession: NZ_CP062320
• Organism: Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF771_RS07525
• Protein ID: WP_001801861.1
• Coordinates: 1536315..1536410 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1536438..1536497 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF771_RS07485	1531975..1532601	+	627	Protein_1471	hypothetical protein	-
IF771_RS07490	1532642..1532986	+	345	WP_000627551.1	DUF3969 family protein	-
IF771_RS07495	1533084..1533635	+	552	WP_000414205.1	hypothetical protein	-
IF771_RS07500	1533853..1534494	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
IF771_RS07505	1534608..1534793	-	186	WP_000809857.1	hypothetical protein	-
IF771_RS07510	1534795..1534971	-	177	WP_000375476.1	hypothetical protein	-
IF771_RS07515	1534982..1535365	-	384	WP_000070811.1	hypothetical protein	-
IF771_RS07520	1535969..1536112	-	144	WP_001549059.1	transposase	-
IF771_RS07525	1536315..1536410	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1536438..1536497	-	60	-	-	Antitoxin
IF771_RS07530	1536533..1536634	+	102	WP_001791893.1	hypothetical protein	-
IF771_RS07535	1536612..1536788	-	177	Protein_1481	transposase	-
IF771_RS07540	1536982..1537359	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1505932..1579716	73784

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174259 WP_001801861.1 NZ_CP062320:1536315-1536410 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174259 NZ_CP080620:c3118221-3118048 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT174259 NZ_CP062320:c1536497-1536438 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin