Detailed information of TA system TA174255

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19734..20072
• Replicon: chromosome
• Accession: NZ_CP062320
• Organism: Staphylococcus aureus strain NAS_OP_101

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF771_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 19734..19910 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19898..20072 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF771_RS00085	14969..18754	+	3786	WP_073392894.1	phage tail spike protein	-
IF771_RS00090	18744..18896	+	153	WP_001153681.1	hypothetical protein	-
IF771_RS00095	18943..19230	+	288	WP_001040254.1	hypothetical protein	-
IF771_RS00100	19288..19584	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
IF771_RS00105	19734..19910	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19898..20072	-	175	-	-	Antitoxin
IF771_RS00115	20122..20376	+	255	WP_000611512.1	phage holin	-
IF771_RS00120	20388..21143	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF771_RS14340	21677..21799	+	123	WP_000346420.1	hypothetical protein	-
IF771_RS00125	22041..22868	-	828	WP_000136020.1	alpha/beta hydrolase	-
IF771_RS00130	22941..24140	-	1200	WP_000286484.1	NADH-dependent flavin oxidoreductase	-
IF771_RS00135	24236..24328	+	93	WP_001801779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1..21143	21142

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174255 WP_011447039.1 NZ_CP062320:19734-19910 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174255 NZ_CP080620:2470424-2470531 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174255 NZ_CP062320:c20072-19898 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin