Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2321736..2322253 Replicon chromosome
Accession NZ_CP062318
Organism Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF775_RS11315 Protein ID WP_000113262.1
Coordinates 2321987..2322253 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF775_RS11310 Protein ID WP_000584499.1
Coordinates 2321736..2321987 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF775_RS11280 (2317434) 2317434..2318153 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF775_RS11285 (2318150) 2318150..2318881 + 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
IF775_RS11290 (2318978) 2318978..2320228 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF775_RS11295 (2320483) 2320483..2320845 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF775_RS11300 (2320864) 2320864..2321463 + 600 WP_000162813.1 DsbA family protein -
IF775_RS11305 (2321470) 2321470..2321571 + 102 WP_001791744.1 hypothetical protein -
IF775_RS11310 (2321736) 2321736..2321987 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF775_RS11315 (2321987) 2321987..2322253 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF775_RS11320 (2322288) 2322288..2322359 + 72 Protein_2202 hypothetical protein -
IF775_RS11325 (2322548) 2322548..2324098 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF775_RS11330 (2324284) 2324284..2324751 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF775_RS11335 (2324835) 2324835..2325017 + 183 WP_000230294.1 hypothetical protein -
IF775_RS11340 (2325234) 2325234..2326058 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF775_RS11345 (2326291) 2326291..2326827 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174247 WP_000113262.1 NZ_CP062318:2321987-2322253 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174247 NZ_CP080599:c3144959-3144708 [Nocardiopsis sp. MT53]
TTGAAGACCATGAGCTACACCGAATCCCGCGCCAACTACGCAGCCACCCTCGACGCCGTCGTGAACGACAGAGAAGAAGT
GGTGATCACGAGAGCCGGACACGAACCCGTCGTCATGATGGCCCTGTCCGAGTACGAGACCCTGAAGGAGACCGCCTACC
TCCTGCGCAGCCCGGAGAACGCCCGCCGCCTGGTCTCCGCCATCGAGGAACTGGAGTCCGATCAGGGCATAGAGCGCGAG
TTGGCCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174247 WP_000584499.1 NZ_CP062318:2321736-2321987 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174247 NZ_CP080599:c3144711-3144451 [Nocardiopsis sp. MT53]
GTGAGGCTCGTCTGGTCCCAGAGCGCCTGGGAGGACTACGTCTGGTGGCAGGGGCAGGACCGCAGGATCCTCAAGCGCAT
CAACGCTCTCGTCAAGGACATCGAGCGCAACGGCAACGAGGGCATGGGCAAGCCCGAACCCCTGAGGCACGGCTTCCAGG
GCTACTGGTCCCGCAGGATCACCGACGAGCACCGGCTGGTGTACAAGCTCGCCGGCGACGAGATCCGCATCGCCGCCTGC
CGCTACCACTACGGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References