Detailed information of TA system TA174244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2265463..2265986
• Replicon: chromosome
• Accession: NZ_CP062318
• Organism: Staphylococcus aureus strain NAS_OP_132

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF775_RS11050
• Protein ID: WP_000074046.1
• Coordinates: 2265720..2265986 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF775_RS11045
• Protein ID: WP_000587615.1
• Coordinates: 2265463..2265720 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF775_RS11025 (2260558)	2260558..2261751	+	1194	WP_000675403.1	MFS transporter	-
IF775_RS11030 (2261975)	2261975..2262724	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF775_RS11035 (2262914)	2262914..2264491	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF775_RS11040 (2264641)	2264641..2265105	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF775_RS11045 (2265463)	2265463..2265720	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF775_RS11050 (2265720)	2265720..2265986	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF775_RS11055 (2266299)	2266299..2267375	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF775_RS11060 (2267623)	2267623..2268285	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF775_RS11065 (2268278)	2268278..2269051	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF775_RS11070 (2269403)	2269403..2270587	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174244 WP_000074046.1 NZ_CP062318:2265720-2265986 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174244 NZ_CP080597:c6089371-6089099 [Pseudomonas sp. ERGC3:05]
ATGCTGGTTGAGTGGGCCCCCGCAGCGCGGGCACAACTCCGGCAAATTACTGATTACATCAGCGACCGCAATCCAGTGGC
AGCGCTTGAGCTGAACCAGGCAATAGAAGCCTGTGTGCTGGCGCTATCTCGTAGACCCCACCTTTACCGCCCTGGACGTG
TCGTCGGCACGCGAGAAATGGTGGTGCATCCGAATTATCTGGTCGTCTATCAGGTGACCGACAGCATTCGGGTTCTCTCG
GTTTTACACGCACGCCAGCGATATCCTTCATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174244 WP_000587615.1 NZ_CP062318:2265463-2265720 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174244 NZ_CP080597:c6089549-6089361 [Pseudomonas sp. ERGC3:05]
ATGGACACTTCCTTTTCCTCAGGCATCCCAACAGATACCGAAGCGCAGGCCGACAGCTACGACCGCTGGTTTCGCGCCAA
AGTGCAAGCTGCTCTCGATGACCCAAGCCCAGGTATTCCTCATGATGAGGTGATGGCCGAGATGCGTGAGCTAATCGAAT
CCAAACGCAAGAAAGGCGATGCTGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2