Detailed information of TA system TA174231

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2708230..2708509
• Replicon: chromosome
• Accession: NZ_CP062314
• Organism: Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF776_RS13455
• Protein ID: WP_001802298.1
• Coordinates: 2708230..2708334 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2708330..2708509 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF776_RS13425	2703614..2704396	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
IF776_RS13430	2704464..2705321	+	858	WP_000370924.1	HAD family hydrolase	-
IF776_RS13440	2706026..2706118	-	93	WP_001790138.1	hypothetical protein	-
IF776_RS13445	2706407..2707543	+	1137	WP_000115564.1	SAP domain-containing protein	-
IF776_RS13450	2707586..2708069	+	484	Protein_2617	recombinase family protein	-
IF776_RS13455	2708230..2708334	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2708330..2708509	-	180	-	-	Antitoxin
IF776_RS13465	2708834..2709925	-	1092	WP_000495671.1	lytic regulatory protein	-
IF776_RS13470	2710191..2711171	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF776_RS13475	2711173..2711493	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF776_RS13480	2711645..2712310	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174231 WP_001802298.1 NZ_CP062314:2708230-2708334 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174231 NZ_CP080594:c2807192-2806830 [Cronobacter sakazakii]
ATGGCATGGACGGTAATTTTTACCGATCGTTTTAACGACTGGTATCAGCAGCAGCCCGAAGGATTACAGGATCGTATCGC
CGCGCTCTTATGGAACTTACGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTGAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTACGTGTGCAGTATGGCGGTGAGCCCTGGCGCGTCTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGCGCAGGCAATAAACGAAGCCAGAAACATTTTTATGACGCCTTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCGATGGAGAGACGAAATGAAAACTCTTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT174231 NZ_CP062314:c2708509-2708330 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin