Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2441665..2442182 Replicon chromosome
Accession NZ_CP062314
Organism Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF776_RS12065 Protein ID WP_000113262.1
Coordinates 2441916..2442182 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag IF776_RS12060 Protein ID WP_000584502.1
Coordinates 2441665..2441916 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF776_RS12030 (2437366) 2437366..2438085 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF776_RS12035 (2438082) 2438082..2438813 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF776_RS12040 (2438910) 2438910..2440160 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF776_RS12045 (2440415) 2440415..2440774 + 360 WP_000819847.1 DUF4467 domain-containing protein -
IF776_RS12050 (2440793) 2440793..2441392 + 600 WP_000162813.1 DsbA family protein -
IF776_RS12055 (2441399) 2441399..2441500 + 102 WP_001791744.1 hypothetical protein -
IF776_RS12060 (2441665) 2441665..2441916 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF776_RS12065 (2441916) 2441916..2442182 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF776_RS12070 (2442217) 2442217..2442288 + 72 Protein_2350 hypothetical protein -
IF776_RS12075 (2442477) 2442477..2444027 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF776_RS12080 (2444213) 2444213..2444680 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF776_RS12085 (2444764) 2444764..2444946 + 183 WP_000230294.1 hypothetical protein -
IF776_RS12090 (2445163) 2445163..2445987 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF776_RS12095 (2446220) 2446220..2446756 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174229 WP_000113262.1 NZ_CP062314:2441916-2442182 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174229 NZ_CP080594:2116110-2116388 [Cronobacter sakazakii]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCGCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGCCCCGCTGACGTCGACTTACCGGGCTTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTTATCGTCAATTATGAGGATTACCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT174229 WP_000584502.1 NZ_CP062314:2441665-2441916 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174229 NZ_CP080594:2116388-2116675 [Cronobacter sakazakii]
ATGGCAACGATGTTTAACCCACCGCACCCGGGCAGGCTGGTGCAGGAGTCAATGGAAGCGCTCGGCCTCAGCGCCCGTGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCGACGGTGCAGCGGCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAAAACGAATACGATCTCTTTCAGGCG
CGCCAGTCTGTTGATTTCTCGCACCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References