Detailed information of TA system TA174227

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2416710..2416894
• Replicon: chromosome
• Accession: NZ_CP062314
• Organism: Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF776_RS11930
• Protein ID: WP_000482650.1
• Coordinates: 2416710..2416817 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2416834..2416894 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF776_RS11905	2412072..2412545	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF776_RS11910	2412668..2413879	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF776_RS11915	2414061..2414720	-	660	WP_000831298.1	membrane protein	-
IF776_RS11920	2414780..2415922	-	1143	WP_001176863.1	glycerate kinase	-
IF776_RS11925	2416190..2416576	+	387	WP_000779358.1	flippase GtxA	-
IF776_RS11930	2416710..2416817	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2416834..2416894	-	61	-	-	Antitoxin
IF776_RS11935	2417445..2419208	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
IF776_RS11940	2419233..2420966	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF776_RS11945	2421197..2421364	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174227 WP_000482650.1 NZ_CP062314:2416710-2416817 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174227 NZ_CP080593:8531-8947 [Cronobacter sakazakii]
GTGAACAAAACGTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTACTGAAGCGACT
GGAGCAGGCGGTGCTGCGCGGCCACCGCATCGTGGTCTCGACTATTACCTATTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACGTGCAGCTGGTCGAGGAGTTCTGCGCCCGGCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTCGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGCCACGCCATTGCCGCCGGCGCCGTACTGGTGACGAATAATGTGCGGGAGTTTGAGCGGGTACCGGGACTGGTACTGG
AAGACTGGGTAAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174227 NZ_CP062314:c2416894-2416834 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin