Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2384871..2385394 Replicon chromosome
Accession NZ_CP062314
Organism Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF776_RS11790 Protein ID WP_000074048.1
Coordinates 2385128..2385394 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF776_RS11785 Protein ID WP_000587616.1
Coordinates 2384871..2385128 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF776_RS11760 (2379951) 2379951..2381144 + 1194 WP_000675401.1 MFS transporter -
IF776_RS11765 (2381368) 2381368..2382117 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF776_RS11770 (2382312) 2382312..2383889 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF776_RS11775 (2384057) 2384057..2384512 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF776_RS11780 (2384571) 2384571..2384765 + 195 WP_001790145.1 hypothetical protein -
IF776_RS11785 (2384871) 2384871..2385128 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF776_RS11790 (2385128) 2385128..2385394 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF776_RS11795 (2385749) 2385749..2386825 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF776_RS11800 (2387073) 2387073..2387735 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF776_RS11805 (2387728) 2387728..2388504 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF776_RS11810 (2388900) 2388900..2390087 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174226 WP_000074048.1 NZ_CP062314:2385128-2385394 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174226 NZ_CP080592:c144580-143261 [Cronobacter sakazakii]
ATGCGCCGCACGGCGCGTTTAGCGCTCTGGATGAACGGCCTGCCGGTCGGTTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCATACCGTGGCGCGCAGGTGCGCGATTACTTCGACAACCTGCTCCCGGACAGCGAAAACATCCGGCGGCGGCTGGCG
ATGCGTTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGGCGCGACTGTGTGGGCGCCATCCAGCT
GCTGCCTGCCGGTGAAGCACCGGAAGGGCTTTTTACCATCCGCGCCCGTCCACTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCGTTCCCCGGCCAGCATGGCGGCGAAGAGGAGCTGCGGCTCTCCATCGCGGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGAAGACCAGTGGTGCCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAATATGCAGGCGGATATGCGCACCTCCATTGAAAACGAATGGCTCTGTGCGCAACTGCTGGCGG
CCTGGGATATTCCGGTCGCGCACACGCAGATGGCGCAGTTCGAAGAGCAAAAAGTGCTGATTGTCGAACGCTTCGACCGG
CGTCTTTCGGCCGATGGCCAGTGGTGGCTGCGTCTGCCGCAGGAGGATATGTGCCAGGCGCTGGGCGTTTCGCCGCTGCG
CAAATATCAGGCCGACGGCGGGCCGGGCATCGGCGATATCATGACGGTTCTGAGCCGTTCAGAAAATGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATTTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATTGCG
CATCTGCCCGGCAACCGCTACCACCTGACGCCGCTTTACGACGTCCTTTCCGCCTGGCCGGTCATCGGGCCCGGTAATAA
CCAGATAGCCTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCAGCGGCAGTAACTATTACCATCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCTGCGGTGATCGCGCGCGTGGCCGACGCGCTCCCGGTGGATTTCCCCGCCTCTCTGGCCGACGTTATTTTTAA
CGGCATGCGCCAGCAGTGCGTGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174226 WP_000587616.1 NZ_CP062314:2384871-2385128 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174226 NZ_CP080592:c144864-144583 [Cronobacter sakazakii]
ATGAACACCCGGTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAAACAGGGGCTGAC
CCAGAAAGAGGTTTCGGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAAACGGCCAGCA
TCGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCGGAGACTGACGCG
CCCGCGCGTGACGATTCGCCTGCCCACCGCGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References