Detailed information of TA system TA174223

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 179938..180120
• Replicon: chromosome
• Accession: NZ_CP062314
• Organism: Staphylococcus aureus strain NAS_OP_133

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF776_RS01085
• Protein ID: WP_001801861.1
• Coordinates: 180025..180120 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	179938..179997 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF776_RS01070	179076..179453	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
IF776_RS01075	179647..179823	+	177	Protein_177	transposase	-
IF776_RS01080	179801..179902	-	102	WP_001791893.1	hypothetical protein	-
-	179938..179997	+	60	-	-	Antitoxin
IF776_RS01085	180025..180120	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF776_RS01090	180323..180466	+	144	WP_001549059.1	transposase	-
IF776_RS01095	181070..181453	+	384	WP_000070811.1	hypothetical protein	-
IF776_RS01100	181464..181640	+	177	WP_000375476.1	hypothetical protein	-
IF776_RS01105	181642..181827	+	186	WP_000809857.1	hypothetical protein	-
IF776_RS01110	181941..182582	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
IF776_RS01115	182800..183351	-	552	WP_000414205.1	hypothetical protein	-
IF776_RS01120	183449..183793	-	345	WP_000627551.1	DUF3969 family protein	-
IF776_RS01125	183834..184460	-	627	Protein_187	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	150005..217560	67555

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174223 WP_001801861.1 NZ_CP062314:c180120-180025 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174223 NZ_CP080591:c3851651-3851301 [Cronobacter sakazakii]
ATGATAAAACCGTTGTTTTGGGTCGGGCAGGCCAGAAAAGATCTTCAGGCGCTGCCGGAGGATGTACAGGATCTTTTTGG
CTATGCGCTTTATCTGGCGCAGCAGGGCAGACGCCATCCGCAGGCCAGGCCGCTTAAAGGTTTTGGCGGCGCGGGTGTAC
TTGAGGTGGTGGAGGATTATCAGGGGAATGCCTTTCGGGCGGTCTATACCGTGTGCCTGAAAGATGCGATTTATGTCCTG
CACGTATTCCAGAAAAAATCCTCTTCCGGGATTGCCACGCCCCGCCCGGAGATGGAAAAAATTGAACAACGACTGAAAGC
CGCGCAACGCCACGCCGGAGGGCTGAAATGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT174223 NZ_CP062314:179938-179997 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin