Detailed information of TA system TA174213

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2646159..2646421
• Replicon: chromosome
• Accession: NZ_CP062312
• Organism: Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF782_RS13105
• Protein ID: WP_001802298.1
• Coordinates: 2646159..2646263 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2646258..2646421 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF782_RS13090	2642956..2643738	+	783	WP_000908175.1	ABC transporter ATP-binding protein	-
IF782_RS13095	2643806..2644663	+	858	WP_000370926.1	HAD family hydrolase	-
IF782_RS13100	2645321..2645479	-	159	WP_001792784.1	hypothetical protein	-
IF782_RS13105	2646159..2646263	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2646258..2646421	-	164	-	-	Antitoxin
IF782_RS13115	2646705..2647796	-	1092	WP_000495671.1	lytic regulatory protein	-
IF782_RS13120	2648062..2649042	-	981	WP_239794322.1	CDF family zinc efflux transporter CzrB	-
IF782_RS13125	2649044..2649364	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF782_RS13130	2649516..2650181	+	666	WP_001024093.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174213 WP_001802298.1 NZ_CP062312:2646159-2646263 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174213 NZ_CP080590:c337119-336796 [Devosia salina]
ATTTCATGGAAGATTGAAATCCTGAGTGACACGGTGCGGGCGGAGCTTGAAGCTTTGCCGGCTGACCAGATTGCCCGCTT
CCTGCGGATCGGTGAGCTGATCCAGTCTTTGGGGCTGGAGCGCGTTCGCGAGCCCCACGTGAAGCACCTGGAAGGGCCGC
TTTGGGAAATCAGGATGAAGGGCAGGGACGGCATATCCCGCGCTCTGTATGTCGTTGCCAGACCAAAGCGCGTAGTGGTG
GTCAGGATCTTCGTGAAGAAATCCCAAAAGACCCCACGCCGCGAAATCGAGCTCGCCCTGAAGCGAGCGAAGGATGTGAG
ATGA

Antitoxin

Nucleotide

• Length: 164 bp

>AT174213 NZ_CP062312:c2646421-2646258 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin