Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2384566..2385083 Replicon chromosome
Accession NZ_CP062312
Organism Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF782_RS11760 Protein ID WP_000113262.1
Coordinates 2384817..2385083 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF782_RS11755 Protein ID WP_000584499.1
Coordinates 2384566..2384817 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF782_RS11725 (2380264) 2380264..2380983 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF782_RS11730 (2380980) 2380980..2381711 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF782_RS11735 (2381808) 2381808..2383058 - 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
IF782_RS11740 (2383313) 2383313..2383675 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF782_RS11745 (2383694) 2383694..2384293 + 600 WP_000162813.1 DsbA family protein -
IF782_RS11750 (2384300) 2384300..2384401 + 102 WP_001791744.1 hypothetical protein -
IF782_RS11755 (2384566) 2384566..2384817 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF782_RS11760 (2384817) 2384817..2385083 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF782_RS11765 (2385118) 2385118..2385189 + 72 Protein_2287 hypothetical protein -
IF782_RS11770 (2385378) 2385378..2386928 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF782_RS11775 (2387114) 2387114..2387581 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF782_RS11780 (2387665) 2387665..2387847 + 183 WP_000230294.1 hypothetical protein -
IF782_RS11785 (2388064) 2388064..2388888 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF782_RS11790 (2389121) 2389121..2389657 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174212 WP_000113262.1 NZ_CP062312:2384817-2385083 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174212 NZ_CP080590:c258301-257984 [Devosia salina]
ATGCCCCAGGGTGACAAGAGCGCCTATACCGACAAGCAGAAGCGCAAGGCCGAGCATATCGAGGAGCGTTACGAGGATCG
TGGCGTATCGCATAAGGAGGCCGAGCGGCGCGCCTGGGCCACCGTCAACAAGGATGATGGCGGCGGCAACAAGTCCGGCT
CCGGACGCGGCACGCACAAAGATCATCCTGCCGCCCACAAGGGTGGCAAGAAGGGCGGCGAAGCCTCGGCCAATCGGCCC
GCATCGGAGCGCTCAGCTTCCGCAAAAAAGGCCGCCGCAACCCGCAAGCGGAACCAAGAGCACCACGCGCATCACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174212 WP_000584499.1 NZ_CP062312:2384566-2384817 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174212 NZ_CP080590:c257974-257111 [Devosia salina]
ATGTCCGGCTCGGCCGCCAAGCCCATGAACCCGCCCCAGACCCAGGACCATCAGCCGGGGCGGGAAAGCGAAATGCATCC
CAAGCCCGATTACATGCCGAAATTCCCCGGCAATGGGCGCCTCAAGGACAAGGTCGCCATCATCACCGGTGGCGATAGCG
GGATCGGGCGTGCCTGCGCCGTCCTCTTTGCCCGTGAAGGGGCCGAGGTGGCGCTGGTCTATCTCGAAGAGACCGATGAC
GCGAGGCTCACTGCCGAGGCCGTCAAGGCGGAGGGCAAGGAGGCGCTGCTGCTGCGCGGCGATGTCAGCGACAAGGCGGT
TTGCGAGAGTGTGGTCGGCCAGGTGGTCGAAAAATTCGGCAAGCTCGATGTGCTGGTCAACAACGCGGCCGAGCAGCATA
TGCAGACCGAGCTCGAGGCCATTTCCGAAGAGCAGTTGCGGCGCACCTTCGAGACCAATTTCTTTGGCTATATGTTCATG
ACGCAGGCCGCGCTGCCGCATCTGAGAAAGGGGTCGGCGATCGTCAACACGACATCGATCACGGCCTATCGGGGCTCGCC
GTCACTGATGGATTATGCCGCGACCAAGGGCGCCATCGTCGCCTTTACCCGATCGCTCTCGGAAAGCCTTGCCGGCAAGG
GTATCCGCGTCAATGGCGTCGCACCCGGCCCGATCTGGACGCCGCTGATCCCGGCCAGTTTCCCGGCCGACAAGGTGGCG
GAATTCGGGGCCAGCCAGCCATTGGGCCGGCCGGGCCAGCCCAATGAGGTGGCAACGAGCCACCTGTTCCTCGCCTGCGA
AGAGAGTTCCTACATCACCGGGCAGGTGCTGCACCCCAATGGCGGGGAGATCATCGGGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References