Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2327636..2328159 Replicon chromosome
Accession NZ_CP062312
Organism Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag IF782_RS11485 Protein ID WP_000074045.1
Coordinates 2327893..2328159 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag IF782_RS11480 Protein ID WP_000587619.1
Coordinates 2327636..2327893 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF782_RS11460 (2322700) 2322700..2323893 + 1194 WP_000675402.1 MFS transporter -
IF782_RS11465 (2324131) 2324131..2324880 - 750 WP_000072440.1 CPBP family lipoprotein N-acylation protein LnsB -
IF782_RS11470 (2325075) 2325075..2326652 + 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
IF782_RS11475 (2326820) 2326820..2327275 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF782_RS11480 (2327636) 2327636..2327893 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF782_RS11485 (2327893) 2327893..2328159 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
IF782_RS11490 (2328515) 2328515..2329591 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF782_RS11495 (2329839) 2329839..2330501 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IF782_RS11500 (2330494) 2330494..2331270 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF782_RS11505 (2331666) 2331666..2332853 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T174209 WP_000074045.1 NZ_CP062312:2327893-2328159 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T174209 NZ_CP080589:c2805809-2804958 [Xanthomonas oryzae pv. oryzicola]
ATGAGCAACGTCGCCGCTTCCGTGCGCGCCCGCCTGCGGGGCGTCGCCAAGGCGCAGGGCGTGGATTTCAATCAGGTGCT
GGTGCGCTTCGCGCTGGAGCGCATCCTTTACCGCCTGAGCCAGTCCGAGCACGCGGATCGTTTCCTGCTCAAGGGCGCGC
TGCTGTTCACGCTCTGGTATGACATGCCGCACCGGGCCACGCGCGACGCCGACCTGCTGGGCTTCGGCGCGAGCGATCTG
GAGTCCGTGGCCCAGACCTTCCGCGACATCGCCAGCGTCGCCGTGGACGACGGCATCGTGTTCGACCCGGCCTCGGTCGT
CGCAGAAGAAATTCGCAAGGACGCCGGATACGCCGGGGCGCGCATCCTCATCGGCGGCGAGCTGGCCAAGGCGCGGTGCA
GGACGCAGATCGACGTTGGCTTCGGCGATGCGGTCACACCGGCTCCGGTGCACTCGGTCTATCCGGTGTTGCTGGAAGAT
CTGCCTGCGCCTCGCCTGCGCACCTATCCCGTCTACACCGTCATCGCGGAAAAGCTCCACGCCATCGCGCTTCTGGGTAT
GACCAACAGTCGGATGAAGGATTACCTCGACCTGTCGGTGCTGCTGGAACGCGAATCCCTGGACATCGATCTGCTGGCGC
AAGCGGTGAAGGCCACTTTCGAGCGACGCGGCATGGCCGTGCCCGCTGCTCTGCCGATCGGCATGACCGACGAGTTCGCG
CACGACACGTCTCGGCAGGCGTTGTGGCAGGCATTCCTCAAGAAGAACGAACTCGCCCCCGAACCCCTGGCTGCCATCGT
GGTTCGACTGCGGGCGGCCTTGGAACCAGCGTTGCACCGGGCTGCTCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT174209 WP_000587619.1 NZ_CP062312:2327636-2327893 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174209 NZ_CP080589:c2806411-2805806 [Xanthomonas oryzae pv. oryzicola]
ATGCTTTCCGACACCCACACCCAGCGCGTCCTCGATCTGGCCAGCCAGAAAGGACTGCTGCGCGCCAGCGATCTGGACGC
CATCAATGCGCCCCGGGTCGTTCTCACGCGCCTGACCGCTGCTGGCGTTCTGGAAAGGGTCGGACGCGGGCTGTACCGCC
TGCCGGACGCGCAGGGATCGGAATTCGAGAGTCTCGCGGCCATCGCCACCAAGGTGCCACAAGCCGTGTTCTGCCTGCTG
ACTGCGCTGCAGTTCCACGAACTGACCACGCAACTGCCGCGCCAGATCTGGATCGCCATGCCGCGCGGCAGTCACGCGCC
CCGGATCGGCTATCCGCCGGTCAAGATGGTTCAGATGACCGGCGACGTCTACGCTGCAGGCATCGAGGAGCACCTGCGCG
ACGGCGTGAGGCTGCGCGTGTACGGTGCGGCCAAGACGGTCGTGGACTGCTTCAAGCACCGCAACAAGATCGGCCTGGAC
GTGGCGCTGGAGGCGCTGAAGGACGTGCGCGCCAAACGCAAGGCCACTGCGGACGACCTGTGGCGCTTTGCTACGGTCTG
CCGCGTGGCCAACGTGATGCGCCCCTATCTGGAGGCGGTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References