Detailed information of TA system TA174204

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 504734..505313
• Replicon: chromosome
• Accession: NZ_CP062312
• Organism: Staphylococcus aureus strain NAS_OP_163

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IF782_RS02725
• Protein ID: WP_001025401.1
• Coordinates: 504734..504979 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	504948..505313 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF782_RS02675 (500855)	500855..501469	+	615	WP_031844332.1	hypothetical protein	-
IF782_RS02680 (501466)	501466..501612	-	147	WP_001013104.1	hypothetical protein	-
IF782_RS02685 (501648)	501648..501830	-	183	WP_000705243.1	hypothetical protein	-
IF782_RS02690 (502030)	502030..502761	-	732	WP_031793402.1	XRE family transcriptional regulator	-
IF782_RS02695 (502913)	502913..503125	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
IF782_RS02700 (503173)	503173..503616	+	444	WP_000435357.1	hypothetical protein	-
IF782_RS02705 (503631)	503631..503780	+	150	WP_000771849.1	hypothetical protein	-
IF782_RS02710 (503821)	503821..504033	-	213	WP_000362644.1	hypothetical protein	-
IF782_RS02715 (504103)	504103..504300	+	198	WP_001148860.1	hypothetical protein	-
IF782_RS02720 (504287)	504287..504667	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
IF782_RS02725 (504734)	504734..504979	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IF782_RS02730 (504948)	504948..505313	-	366	WP_001128433.1	hypothetical protein	Antitoxin
IF782_RS02735 (505368)	505368..505583	+	216	WP_001097553.1	hypothetical protein	-
IF782_RS02740 (505608)	505608..505871	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IF782_RS02745 (505883)	505883..506044	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
IF782_RS02750 (506123)	506123..506446	+	324	WP_000174998.1	hypothetical protein	-
IF782_RS02755 (506461)	506461..506823	+	363	WP_000279448.1	hypothetical protein	-
IF782_RS02760 (506820)	506820..507986	+	1167	WP_000762531.1	DUF2800 domain-containing protein	-
IF782_RS02765 (508012)	508012..508569	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T174204 WP_001025401.1 NZ_CP062312:504734-504979 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T174204 NZ_CP080588:c9309-8983 [Xanthomonas oryzae pv. oryzicola]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCACGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGCATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGTAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT174204 NZ_CP062312:c505313-504948 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin