Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 622690..623192 Replicon chromosome
Accession NZ_CP062254
Organism Pectobacterium parmentieri strain QK-5

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8B3FFY4
Locus tag IG623_RS03005 Protein ID WP_025919527.1
Coordinates 622690..622944 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B3FIJ8
Locus tag IG623_RS03010 Protein ID WP_033070807.1
Coordinates 622941..623192 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG623_RS02985 617796..619058 - 1263 WP_012822274.1 L-rhamnose isomerase -
IG623_RS02990 619055..620545 - 1491 WP_012822275.1 rhamnulokinase -
IG623_RS02995 620914..621753 + 840 WP_005971146.1 HTH-type transcriptional activator RhaS -
IG623_RS03000 621778..622632 + 855 WP_012822276.1 helix-turn-helix domain-containing protein -
IG623_RS03005 622690..622944 - 255 WP_025919527.1 Txe/YoeB family addiction module toxin Toxin
IG623_RS03010 622941..623192 - 252 WP_033070807.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IG623_RS03015 623267..624955 - 1689 WP_025919529.1 ABC transporter ATP-binding protein -
IG623_RS03020 624952..625818 - 867 WP_012822280.1 ABC transporter permease -
IG623_RS03025 625811..626770 - 960 WP_012822281.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtB / hcp 539323..682094 142771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10135.66 Da        Isoelectric Point: 8.0367

>T174175 WP_025919527.1 NZ_CP062254:c622944-622690 [Pectobacterium parmentieri]
VKPIWSEAAWEDYLYWQDIDNRIVKKINELIKEIRRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYAITDDAMMIAAC
RYHY

Download         Length: 255 bp

>T174175 NZ_CP080566:c849769-849581 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.64 Da        Isoelectric Point: 4.6119

>AT174175 WP_033070807.1 NZ_CP062254:c623192-622941 [Pectobacterium parmentieri]
MRTISYSEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANAKRLMNAIESLKAGNGEERD
IIE

Download         Length: 252 bp

>AT174175 NZ_CP080566:c850058-849798 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3FFY4

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3FIJ8

References